Anti-SARM1 Antibody Biotin Conjugate (1561353)

Name: Anti-SARM1 Antibody Biotin Conjugate
Brand: Antibodies Incorporated
SKU: 77-522-BTN
Price: 543.0 USD
Availability: InStock

Our mouse SARM1 biotin conjugate monoclonal antibody from Antibodies Incorporated is produced in-house from clone 1561353. It detects human, mouse, and rat SARM1 and is purified by Protein A chromatography. Works in ELISA, IHC, ICC, WB.

Anti-SARM1 Antibody Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Trial Size

SKU: 77-522-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

SARM1

Scientific Background

SARM1 ( Sterile Alpha and TIR Motif-Containing 1) is predominantly expressed in the nervous system, particularly in neurons, and is highly conserved across different species. It encodes a protein that contains several functional domains, including a sterile alpha motif (SAM) domain, a Toll/interleukin-1 receptor (TIR) domain, and a catalytic domain with NAD^+ hydrolase activity. SARM1 activation triggers a cascade of molecular events that leads to the breakdown of axonal structures and eventual degeneration. In response to injury, SARM1 is activated and catalyzes cleavage of NAD+ into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide. In the nervous system, NAD+ depletion is a critical step in the axonal degeneration process, known as Wallerian degeneration, and is essential for clearing damaged axons to allow for regeneration and repair. Inhibition of SARM1 or the preservation of NAD+ levels has been shown to protect axons from degeneration in experimental models, suggesting SARM1 as a potential therapeutic target for neurodegenerative diseases and nerve injuries. Research on SARM1 has primarily focused on its role in axonal degeneration and neuroprotection. Understanding the molecular mechanisms underlying SARM1 activation and its downstream effects may have implications for developing treatments for various neurological disorders, such as peripheral neuropathies, traumatic brain injury, and neurodegenerative diseases like Parkinson's and Alzheimer's.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

1561353

Isotype

IgG2b

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

SARM1

Molecular Weight

73 kDa

Immunogen

Fusion Protein Amino acids 51-724 of human SARM1 (accession number Q6SZW1) produced recombinantly in E. Coli.

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

FLJ36296 antibody; KIAA0524 antibody; MyD88-5 antibody; SAM and ARM-containing protein antibody; SAM domain-containing protein 2 antibody; SAMD2 antibody; SARM 1 antibody; SARM1 antibody; SARM1_HUMAN antibody; Sterile alpha and Armadillo repeat protein antibody; sterile alpha and HEAT/Armadillo motif protein; ortholog of Drosophila antibody; sterile alpha and HEAT/Armadillo motifs-containing protein antibody; sterile alpha and TIR motif containing 1 antibody; Sterile alpha and TIR motif-containing protein 1 antibody; Sterile alpha and TIR motifs-containing protein 1 antibody; Sterile alpha motif domain-containing protein 2 antibody; Tir-1 homolog antibody

UniProt ID

Q6SZW1
UniProt Summary: NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.

NCBI Gene ID

23098

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Anti-SARM1 Antibody Biotin Conjugate (1561353)

SKU: 77-522-BTN

Product Details

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