Anti-CSPG4/NG2 Antibody Biotin Conjugate (6203-34)

Name: Anti-CSPG4/NG2 Antibody Biotin Conjugate
Brand: Antibodies Incorporated
SKU: 77-523-BTN
Price: 543.0 USD
Availability: InStock

Our mouse CSPG4/NG2 biotin conjugate monoclonal antibody from Antibodies Incorporated is produced in-house from clone 6203-34. It detects human, mouse, and rat CSPG4/NG2 and is purified by Protein A chromatography. Works in ELISA, IHC, WB.

Anti-CSPG4/NG2 Antibody Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Trial Size

SKU: 77-523-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

CSPG4/NG2

Scientific Background

Neuron-glial antigen 2 (NG2) is a chondroitin sulfate proteoglycan that is encoded by the CSPG4 gene in humans. It is an excellent oligodendrocyte marker. NG2 is a hallmark protein of oligodendrocyte progenitor cells (OPCs) and has been linked with familial schizophrenia (de Vrij, F.M., et al, 2018). NG2 also plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells (Luo, W., et al, 2006). NG2 localizes at the apical plasma membrane and relocalizes to the lamellipodia of astrocytoma upon PRKCA phosphorylation.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

6203-34

Isotype

IgG1

Applications

ELISA, IHC, WB

Host Species

Mouse

Gene Name

CSPG4/NG2

Molecular Weight

250 kDa

Immunogen

Fusion Protein Amino acids S1583-S2224 of human CSPG4/NG2 (accession number Q6UVK1) produced in CHO cells

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

4732461B14Rik antibody; AN2 antibody; AN2 proteoglycan antibody; Chondroitin sulfate proteoglycan 4 (melanoma-associated antibody; Chondroitin sulfate proteoglycan 4 antibody; Chondroitin sulfate proteoglycan NG2 antibody; Cspg4 antibody; Cspg4 chondroitin sulfate proteoglycan 4 antibody; CSPG4_HUMAN antibody; HMW-MAA antibody; HSN tumor-specific antigen antibody; Kiaa4232 antibody; MCSP antibody; MCSPG antibody; MEL-CSPG antibody; Melanoma chondroitin sulfate proteoglycan antibody; Melanoma-associated chondroitin sulfate proteoglycan antibody; MELCSPG antibody; MSK16 antibody; NG2 antibody

UniProt ID

Q6UVK1
UniProt Summary: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Also functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

NCBI Gene ID

1464

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Anti-CSPG4/NG2 Antibody Biotin Conjugate (6203-34)

SKU: 77-523-BTN

Product Details

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