Anti-Parvalbumin Recombinant Chicken Chimeric mAb Biotin Conjugate (L114/81)

Name: Anti-Parvalbumin Recombinant Chicken Chimeric mAb Biotin Conjugate
Brand: Aves Labs
SKU: 78-479-BTN
Price: 562.0 USD
Availability: InStock

Our chicken Parvalbumin biotin conjugate recombinant antibody from Aves Labs is produced in-house from clone L114/81. It detects mouse and rat Parvalbumin and is purified by affinity chromatography. Works in ELISA, ICC, IHC, WB.

Anti-Parvalbumin Recombinant Chicken Chimeric mAb Biotin Conjugate

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Species Reactivity

Mouse, Rat

Applications

AT, ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

Trial Size

SKU: 78-479-BTN

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Parvalbumin

Scientific Background

Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer (Permyakov EA et al., 2017). Parvalbumin (PV)-expressing interneurons are a class of inhibitory neurons that fire rapid barrages of action potentials, and are accordingly named “fast-spiking” interneurons (Trachtenberg J. 2015).

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

L114/81

Isotype

IgY

Applications

AT, ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

Pvalb Pva

Molecular Weight

12 kDa

Immunogen

Fusion Protein Amino acids 1-110 (full-length) of rat Parvalbumin (accession number P02625) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of our NeuroMab clone L114/81 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone L114/81 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

bA122O1.1 antibody; Parvalbumin alpha; GABA and glycine transporter antibody; hVIAAT antibody; SLC32A1 antibody; SLC32A 1 antibody; solute carrier family 32 (GABA vesicular transporter member 1 antibody; Solute carrier family 32 member 1 antibody; Vesicular GABA Amino Acid Transporter antibody; Vesicular GABA transporter antibody; Vesicular inhibitory amino acid transporter antibody; VGAT antibody; VIAAT antibody; VIAAT_HUMAN antibody

UniProt ID

Q9H598
UniProt Summary: Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake.

NCBI Gene ID

140679

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Anti-Parvalbumin Recombinant Chicken Chimeric mAb Biotin Conjugate (L114/81)

SKU: 78-479-BTN

Product Details

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