Anti-Calretinin Recombinant Chicken Chimeric mAb Biotin Conjugate (L122/6)

Name: Anti-Calretinin Recombinant Chicken Chimeric mAb Biotin Conjugate
Brand: Aves Labs
SKU: 78-488-BTN
Price: 562.0 USD
Availability: InStock

Our chicken Calretinin biotin conjugate recombinant antibody from Aves Labs is produced in-house from clone L122/6. It detects human, mouse, and rat Calretinin and is purified by affinity chromatography. Works in ELISA, ICC, IHC, WB.

Anti-Calretinin Recombinant Chicken Chimeric mAb Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

Trial Size

SKU: 78-488-BTN

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Calretinin

Scientific Background

Calretinin is a calcium-binding protein involved in calcium signaling. It is abundantly expressed throughout the central nervous system, retina and many other tissues. Studies have shown that calretinin may play a role in neuroprotection by buffering intracellular calcium (Lukas and Jones 1994, Weisenhorn et al., 1996). Additionally, calretinin selectively stains mesothelial cells thus making it an important marker for differentiating malignant mesothelioma from carcinomas (Attanoos et al., 2000).

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

L122/6

Isotype

IgY

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

CALB2 CAB29

Molecular Weight

25-35 kDa

Immunogen

Fusion Protein Amino acids 1-178 (N-terminus) of human CALB2 (accession number) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of our NeuroMab clone L122/6 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone L122/6 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

29 kDa calbindin antibody; CALB2; CAB 29 antibody; Calretinin; CAB29 antibody; 29 kDa calbindin; CAL 2 antibody; CAL2 antibody; CALB 2 antibody; CALB2 antibody; CALB2_HUMAN antibody; Calbindin 2 29kDa antibody; Calbindin 2 antibody; Calbindin D29K antibody; Calbindin2 antibody; Calretinin antibody; CR antibody

UniProt ID

P22676
UniProt Summary: Calcium-binding protein involved in calcium homeostasis and signal transduction. It plays a critical role in buffering intracellular calcium levels and modulating calcium-dependent signaling pathways. Predominantly expressed in specific neuronal populations, influences synaptic plasticity and neuronal excitability, contributing to learning and memory. During embryonic development, it facilitates neuronal differentiation and maturation.

NCBI Gene ID

794

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Anti-Calretinin Recombinant Chicken Chimeric mAb Biotin Conjugate (L122/6)

SKU: 78-488-BTN

Product Details

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