Anti-Kv6.4 Potassium Channel Antibody Biotin Conjugate (N458/10)

Name: Anti-Kv6.4 Potassium Channel Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-458-BTN
Price: 543.0 USD
Availability: InStock

Our mouse Kv6.4 potassium channel biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N458/10. It detects human, mouse, and rat Kv6.4 potassium channel and is purified by Protein A chromatography. Works in ELISA, ICC, WB.

Anti-Kv6.4 Potassium Channel Antibody Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-458-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Kv6.4 potassium channel

Scientific Background

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. Members of the Kv5-Kv11 families code for “silent subunits” that do not express as functional homomultimers. In heterologous expression systems, silent subunits can coassemble with Kv2 and Kv3 subunits and modulate the biophysical characteristics of the latter subunits (Yan L. et al., 2004).

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N458/10

Isotype

IgG2a

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

Kcng4

Molecular Weight

60-80 kDa

Immunogen

Fusion Protein Amino acids 1-219 (cytoplasmic N-terminus) of mouse Kv6.4 (accession number Q80XM3) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

4921535I01Rik; Potassium voltage-gated channel subfamily G member 4; KV6.3; Voltage-gated potassium channel subunit Kv6.4; KV6.4; voltage-gated potassium channel subunit Kv6.3

UniProt ID

Q80XM3
UniProt Summary: Regulatory subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, modulates the kinetics parameters of the heterotetrameric channel namely the time course of activation, deactivation and inactivation and on the voltage-dependence of activation. Potassium channel subunit that does not form functional channels by itself. Reduces the deactivation rate. Modulates the threshold for activation by shifting by approximately 20 mV in hyperpolarizing direction. Markedly changes the inactivation by shifting the voltage dependence of inactivation by approximately 40 mV in hyperpolarizing direction. Acceleratee activation and enhances the time course of activation.

NCBI Gene ID

66733

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Anti-Kv6.4 Potassium Channel Antibody Biotin Conjugate (N458/10)

SKU: 75-458-BTN

Product Details

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