Anti-Kv6.4 Potassium Channel Antibody (N458/10)

Name: Anti-Kv6.4 Potassium Channel Antibody
Brand: NeuroMab
SKU: 75-458
Price: 319.0 USD
Availability: InStock

1 Citation

Our Anti-Kv6.4 potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N458/10. It detects mouse and rat Kv6.4 potassium channel, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Immunoblot against extracts of COS cells transiently transfected with Myc/Flag-tagged Kv6.1, Kv6.4 or untagged Kv2.1 plasmid probed with N458/10 (left) or rabbit anti-Flag (right)..

Species Reactivity

Human, Mouse, Rat

Applications

ICC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-458

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

Kv6.4 potassium channel

Target Description

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. Members of the Kv5-Kv11 families code for “silent subunits” that do not express as functional homomultimers. In heterologous expression systems, silent subunits can coassemble with Kv2 and Kv3 subunits and modulate the biophysical characteristics of the latter subunits (Yan L. et al., 2004).

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N458/10

Isotype

IgG2a

Applications

ICC, WB

Host Species

Mouse

Gene Name

Kcng4

Molecular Weight

60-80 kDa

Antigen

Fusion protein amino acids 1-219 (cytoplasmic N-terminus) of mouse Kv6.4 (accession number Q80XM3) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2716262

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4)

UniProt Details

UniProt (Human): Q8TDN1
UniProt (Immunogen Species): Q80XM3

Product Specific References for Applications and Species

Immunocytochemistry: Human

Immunocytochemistry: Human
PMID	Dilution	Publication
32697988	not listed	Lee, M.C., et al. . Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit. Cell Reports, 107941.

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Anti-Kv6.4 Potassium Channel Antibody (N458/10)

SKU: 75-458

Product Details

Product Specific References for Applications and Species

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