Anti-Kv9.2 Antibody Biotin Conjugate (N460/19)

Name: Anti-Kv9.2 Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-459-BTN
Price: 543.0 USD
Availability: InStock

Our mouse Kv9.2 biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N460/19. It detects mouse and rat Kv9.2 and is purified by Protein A chromatography. Works in ELISA, ICC, WB.

Anti-Kv9.2 Antibody Biotin Conjugate

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Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-459-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Kv9.2

Scientific Background

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. Members of the Kv5-Kv11 families code for “silent subunits” that do not express as functional homomultimers. In heterologous expression systems, silent subunits can coassemble with Kv2 and Kv3 subunits and modulate the biophysical characteristics of the latter subunits (Yan L. et al., 2004).

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N460/19

Isotype

IgG1

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

Kcns2

Molecular Weight

60-80 kDa

Immunogen

Fusion Protein Amino acids 411-477 (cytoplasmic C-terminus) of mouse Kv9.2 (accession number O35174) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

E130006J24Rik; Kv9.2; delayed-rectifier K(+ channel alpha subunit 2; Potassium voltage-gated channel subfamily S member 2; voltage-gated potassium channel subunit Kv9.2; Delayed-rectifier K(+ channelalpha subunit 2; Kcns20; KIAA1144

UniProt ID

O35174
UniProt Summary: Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process.

NCBI Gene ID

16539

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Anti-Kv9.2 Antibody Biotin Conjugate (N460/19)

SKU: 75-459-BTN

Product Details

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