Anti-GluN2C/NR2C Antibody Biotin Conjugate (N422/18)

Name: Anti-GluN2C/NR2C Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-411-BTN
Price: 543.0 USD
Availability: InStock

Our mouse GluN2C/NR2C biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N422/18. It detects human, mouse, and rat GluN2C/NR2C and is purified by Protein A chromatography. KO validated. Works in ELISA, IHC, ICC, WB.

Anti-GluN2C/NR2C Antibody Biotin Conjugate

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

Go to Full Product Details

Data Sheet

KO Validated

SKU: 75-411-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GluN2C/NR2C

Scientific Background

Glutamate receptor ionotropic, NMDA 2C, Nmethyl D-aspartate receptor subtype 2C, or GluN2C/NR2C is encoded by the gene GRIN2C. GluN2C is a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of channel forming ionotropic glutamate receptor which is permeable to cations including calcium, potassium and sodium. GluN2C is found in the central nervous system and the cerebellum. GluN2C is thought to have an important role in physiological processes such as learning, memory, and synaptic development. Diseases associated with this gene include Alzheimer disease, Parkinson’s disease and Schizophrenia.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N422/18

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Grin2c

Molecular Weight

130 kDa

Immunogen

Fusion Protein Amino acids 836-1233 (cytoplasmic C-terminus) of rat GluN2C (accession number Q00961) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

GluN2C antibody; Glutamate receptor ionotropic; Glutamate [NMDA receptor subunit epsilon-3 antibody; GluN2C; Glutamate Receptor Ionotropic N Methyl D Aspartate 2C antibody; Glutamate [NMDA receptor subunit epsilon-3; Glutamate receptor ionotropic NMDA 2C antibody; N-methyl D-aspartate receptor subtype 2C; NMDAR2C; Grin2c antibody; NR2C; Grin 2c antibody; N Methly D Aspartate Receptor Channel Subunit Epsilon 3 antibody; N Methyl D Aspartate Receptor Subtype 2C antibody; N methyl D aspartate receptor subunit 2C antibody; N-methyl D-aspartate receptor subtype 2C antibody; NMDAR2C antibody; NMDE3_HUMAN antibody; NR2C antibody; OTTHUMP00000041930 antibody; NMDA 2C

UniProt ID

Q00961
UniProt Summary: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.

NCBI Gene ID

24411

Shipping

Shipped on ice packs

Recover password

Create my account

Anti-GluN2C/NR2C Antibody Biotin Conjugate (N422/18)

SKU: 75-411-BTN

Product Details

Bulk Order Anti-GluN2C/NR2C Antibody Biotin Conjugate

Related Products

Recently Viewed