Immunofluorescence staining of sections from adult GluN2C/NR2C wild-type (WT) and knockout (KO) mouse cerebellum with N422/18 (GluN2C/NR2C, red) and L106/83 (Gephyrin, green) TC supe. Tissue courtesy of Sharon Swanger and Stephen Traynelis (Emory).
Glutamate receptor ionotropic, NMDA 2C, Nmethyl D-aspartate receptor subtype 2C, or GluN2C/NR2C is encoded by the gene GRIN2C. GluN2C is a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of channel forming ionotropic glutamate receptor which is permeable to cations including calcium, potassium and sodium. GluN2C is found in the central nervous system and the cerebellum. GluN2C is thought to have an important role in physiological processes such as learning, memory, and synaptic development. Diseases associated with this gene include Alzheimer disease, Parkinson’s disease and Schizophrenia.
ICC, IHC, WB
Fusion protein amino acids 836-1233 (cytoplasmic C-terminus) of rat GluN2C (also known as Glutamate receptor ionotropic NMDA 2C, Glutamate [NMDA] receptor subunit epsilon-3, Nmethyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C and Grin2c, accession number Q00961); Mouse: 93% identity (372/400 amino acids identical); Human: 72% identity (293/405 amino acids identical); 30% identity with GluN2D/NR2D and other GluN/NMDA receptors
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.