Anti-GAD67 Antibody Biotin Conjugate (L127/8)

Name: Anti-GAD67 Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-507-BTN
Price: 543.0 USD
Availability: InStock

Our mouse GAD67 biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone L127/8. It detects human, mouse, and rat GAD67 and is purified by Protein A chromatography. Works in ELISA, IHC, ICC, WB.

Anti-GAD67 Antibody Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

AT, ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-507-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GAD67

Scientific Background

Glutamate decarboxylase 1, GAD67 or GAD1 is a member of the group II decarboxylase family and catalyzes the production of GABA from L-glutamic acid. GAD67 is expressed in brain (throughout the cell), in insulin producing ßcells of the pancreas, and several non-neuronal tissues during development. Alterations in GAD67 have been shown to lead to pyridoxine dependency with seizures. Other disorders associated with GAD67 are Cerebral Palsy, Spastic Quadriplegic, 1 and Inherited Congenital Spastic Tetraplegia.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

L127/8

Isotype

IgG2b

Applications

AT, ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

GAD1, GAD, GAD67

Molecular Weight

70 kDa

Immunogen

Fusion Protein Amino acids 1-594 (full-length) of human GAD67 (accession number Q99259) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

Cross-reacts with GAD25 Does not cross-react with GAD44 or GAD65/GAD2

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

CPSQ1; GAD67; SCP; glutamate decarboxylase 1; 67 kDa glutamic acid decarboxylase; GAD-67; glutamate decarboxylase 1 (brain; 67kDa; glutamate decarboxylase 67 kDa isoform; GAD1; GAD and DCE1

UniProt ID

Q99259
UniProt Summary: Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.

NCBI Gene ID

2571

Shipping

Shipped on ice packs

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Anti-GAD67 Antibody Biotin Conjugate (L127/8)

SKU: 75-507-BTN

Product Details

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