Glutamate decarboxylase 1, GAD67 or GAD1 is a member of the group II decarboxylase family and catalyzes the production of GABA from L-glutamic acid. GAD67 is expressed in brain (throughout the cell), in insulin producing ßcells of the pancreas, and several non-neuronal tissues during development. Alterations in GAD67 have been shown to lead to pyridoxine dependency with seizures. Other disorders associated with GAD67 are Cerebral Palsy, Spastic Quadriplegic, 1 and Inherited Congenital Spastic Tetraplegia.
AT, ICC, IHC, WB
Fusion protein amino acids 1-594 (full-length) of human GAD67 (also known as Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD and DCE1, accession number Q99259); Mouse: 97% identity (577/594 amino acids identical); Rat: 97% identity (577/594 amino acids identical); 100% identity (213/213 amino acids identical) with GAD25; >90% identity (366/391 amino acids identical, highest in N-terminus) with GAD44; >60% identity (375/569 amino acids identical, highest in C-terminus) with GAD2/GAD65/DCE2
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Cross-reacts with GAD25;
Does not cross-react with GAD44 or GAD65/GAD2
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.