Anti-GAD67 Antibody (L127/8)

Name: Anti-GAD67 Antibody
Brand: NeuroMab
SKU: 75-507
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

L127/8

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

GAD1, GAD, GAD67

Molecular Weight

70 kDa

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Western blotting of rat brain homogenate (10 ug/lane) with anti-GAD65/67 (L127/8) at 1:100 dilution and detected with anti-mouse HRP.

Volume: 100 µL

Variant

Price:

$308

Quantity:

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Product Details

Target

GAD67

Target Description

Glutamate decarboxylase 1, GAD67 or GAD1 is a member of the group II decarboxylase family and catalyzes the production of GABA from L-glutamic acid. GAD67 is expressed in brain (throughout the cell), in insulin producing ßcells of the pancreas, and several non-neuronal tissues during development. Alterations in GAD67 have been shown to lead to pyridoxine dependency with seizures. Other disorders associated with GAD67 are Cerebral Palsy, Spastic Quadriplegic, 1 and Inherited Congenital Spastic Tetraplegia.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L127/8

Isotype

IgG2b

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

GAD1, GAD, GAD67

Molecular Weight

70 kDa

Antigen

Fusion protein amino acids 1-594 (full-length) of human GAD67 (accession number Q99259) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2756509

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Cross-reacts with GAD25 Does not cross-react with GAD44 or GAD65/GAD2

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

GAD67, Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD and DCE1

UniProt Details

UniProt (Human): Q99259
UniProt (Immunogen Species): Q99259

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Anti-GAD67 Antibody (L127/8)

Available Conjugates

Anti-GAD67 Antibody
SKU: 75-507

Bulk Order Anti-GAD67 Antibody

Product Details

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Anti-GAD67 Antibody (L127/8)

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Anti-GAD67 Antibody SKU: 75-507

Bulk Order Anti-GAD67 Antibody

Product Details

Anti-GAD67 Antibody
SKU: 75-507