Anti-GAD67 Antibody (L127/8)

Name: Anti-GAD67 Antibody
Brand: NeuroMab
SKU: 75-507
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

L127/8

Applications

AT, ICC, IHC, WB

Host Species

Mouse

Format

Purified

Molecular Weight

70 kDa

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Western blotting of rat brain homogenate (10 ug/lane) with anti-GAD65/67 (L127/8) at 1:100 dilution and detected with anti-mouse HRP.

Volume: 100 µL

Variant

Price:

$308

Quantity:

Bulk Order Anti-GAD67 Antibody

Product Details

Target Description

Glutamate decarboxylase 1, GAD67 or GAD1 is a member of the group II decarboxylase family and catalyzes the production of GABA from L-glutamic acid. GAD67 is expressed in brain (throughout the cell), in insulin producing ßcells of the pancreas, and several non-neuronal tissues during development. Alterations in GAD67 have been shown to lead to pyridoxine dependency with seizures. Other disorders associated with GAD67 are Cerebral Palsy, Spastic Quadriplegic, 1 and Inherited Congenital Spastic Tetraplegia.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L127/8

Isotype

IgG2b

Applications

AT, ICC, IHC, WB

Host Species

Mouse

Molecular Weight

70 kDa

Antigen

Fusion protein amino acids 1-594 (full-length) of human GAD67 (also known as Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD and DCE1, accession number Q99259); Mouse: 97% identity (577/594 amino acids identical); Rat: 97% identity (577/594 amino acids identical); 100% identity (213/213 amino acids identical) with GAD25; >90% identity (366/391 amino acids identical, highest in N-terminus) with GAD44; >60% identity (375/569 amino acids identical, highest in C-terminus) with GAD2/GAD65/DCE2

Species Reactivity

Human, Mouse, Rat

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Cross-reacts with GAD25; Does not cross-react with GAD44 or GAD65/GAD2

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

GAD67, Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD and DCE1

UniProt Details

UniProt (Immunogen Species): Q99259

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Anti-GAD67 Antibody (L127/8)

Anti-GAD67 Antibody
SKU: 75-507

Bulk Order Anti-GAD67 Antibody

Product Details

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Anti-GAD67 Antibody (L127/8)

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Anti-GAD67 Antibody
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