Anti-Doc2B Antibody FL490 Conjugate (N150/21)

Name: Anti-Doc2B Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-214-FL490
Price: 486.0 USD
Availability: InStock

Our mouse Doc2b FL490 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N150/21. It detects mouse and rat Doc2b and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-Doc2B Antibody FL490 Conjugate

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Species Reactivity

Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-214-FL490

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Doc2b

Scientific Background

Double C2-like domain-containing protein beta or Doc2b is encoded by the gene DOC2b. Doc2b functions as a calcium sensor which positively regulates soluble NSF attachment receptor (SNARE) dependent fusion of vesicles with membranes. Doc2b binds phospholipids and may act at the priming stage of membrane fusion by modifying membrane curvature to stimulate fusion. Doc2b is expressed in pancreatic cells, endocrine cells and brain, where it is highly expressed in neurons. (Friedrich et al.Neurosci., July 2, 2008 • 28(27):6794 – 6806)

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N150/21

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Doc2b

Molecular Weight

45 kDa

Immunogen

Fusion protein amino acids 1-216 (N-terminus) of rat Doc2b (accession number P70610) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2939792

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

Does not cross-react with Doc2a

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Double C2-like domain-containing protein beta (Doc2-beta)

UniProt ID

P70610

Shipping

Shipped on ice packs

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Anti-Doc2B Antibody FL490 Conjugate (N150/21)

SKU: 75-214-FL490

Product Details

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