Anti-Doc2B Antibody (N150/21)

Name: Anti-Doc2B Antibody
Brand: NeuroMab
SKU: 75-214
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N150/21

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

Doc2b

Molecular Weight

45 kDa

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Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with GFP-tagged Doc2b or untagged Kv2.1 plasmids and probed with N150/21 (left), N86/8 (middle) and K89/41 (right).

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

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$308

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Product Details

Target

Doc2b

Target Description

Double C2-like domain-containing protein beta or Doc2b is encoded by the gene DOC2b. Doc2b functions as a calcium sensor which positively regulates soluble NSF attachment receptor (SNARE) dependent fusion of vesicles with membranes. Doc2b binds phospholipids and may act at the priming stage of membrane fusion by modifying membrane curvature to stimulate fusion. Doc2b is expressed in pancreatic cells, endocrine cells and brain, where it is highly expressed in neurons. (Friedrich et al.Neurosci., July 2, 2008 • 28(27):6794 – 6806)

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N150/21

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Doc2b

Molecular Weight

45 kDa

Antigen

Fusion protein amino acids 1-216 (N-terminus) of rat Doc2b (also known as Double C2-like domain-containing protein beta and Doc2-beta, accession number P70610); Mouse: 97% identity (210/216 amino acids identical); Human: 93% identity (203/169 amino acids identical); Less than 60% identity with Doc2a

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2315830

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with Doc2a

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Double C2-like domain-containing protein beta (Doc2-beta)

UniProt Details

UniProt (Human): Q14184
UniProt (Immunogen Species): P70610

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Anti-Doc2B Antibody (N150/21)

Anti-Doc2B Antibody
SKU: 75-214

Bulk Order Anti-Doc2B Antibody

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Anti-Doc2B Antibody (N150/21)

Anti-Doc2B Antibody SKU: 75-214

Bulk Order Anti-Doc2B Antibody

Product Details

Anti-Doc2B Antibody
SKU: 75-214