Polyclonal Antibodies

1041 products

Polyclonal antibodies recognize multiple epitopes on the same target protein and therefore can offer strong signal-to-noise as the binding at multiple sites allows for many detection molecules to bind.

Antibodies Inc is proud to offer several product lines and flavors of polyclonal antibodies. Rabbit polyclonals are an industry standard for polyclonal antibodies because the medium size of rabbits allows for larger pools of serum. With a focus in both neuroscience and cancer research, our PhosphoSolutions line specializes in phosphospecific rabbit polyclonal antibodies.

Chicken polyclonals have grown in popularity especially when performing multiplex analysis using secondary antibodies. We offer the complete product line from Aves Labs: a pioneer in the use of chickens for the production of polyclonal research antibodies. Evolutionarily removed from mammals, chickens mount a vigorous immune response to mammalian gene products, resulting in high-affinity IgY antibodies. A unique species like chicken is also perfect for multiplexing applications, with low cross-reactivity to other species.

Antibodies Inc offers polyclonal centromere antibodies which are purified IgG derived from human anti-centromere positive serum (CREST patient serum). Useful as diagnostic markers in assays such as IHC and ICC, as well as controls in ANA diagnostics, they help identify autoimmune reactions.

Showing 73 - 96 of 1041 products

Neurosphere (organoid) cultures of e13 mouse brain were cultured for 2 weeks, and then paraformaldehyde (2%) fixed. After extensive washing, the cultures were incubated with Netrin-1 antibody (Cat. NET; 1:500 dilution), washed, and then treated with fluorescein-labeled goat anti-chicken IgY (Aves Cat. No. F-1005; 1:500 dilution). Hoda Ilias, Aves Labs.

Aves Labs Anti-Netrin-1 Antibody

$481

Western blot of 20 ug of mouse heart lysate showing specific immunolabeling of the ~25 kDa cardiac troponin I protein.

Western blots showing specific labeling of S23/S24 TnI, cat. p2010-2324 (upper) and TnI; cat. 2010-TnI (lower) in protein lysates of mouse cardiomyocytes. Image from publication CC-BY-4.0. PMID: 36424916

PhosphoSolutions Anti-Troponin I (cardiac) Antibody

From $154

Immunolabeling of a section of mouse piriform cortex labeled with Anti-Phospho-Ser133 CREB (Cat. p1010-133, red, 1:1000). Cell nuclei are visualized with DAPI DNA stain (blue).

Western blot of rat hippocampal lysate stimulated with forskolin showing specific immunolabeling of the ~45 kDa CREB phosphorylated at Ser133 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by lysate treatment with lambda phosphatase (λ-Ptase, 800 units/1mg protein for 30 min).

PhosphoSolutions Anti-CREB (Ser133) Antibody

From $164

Western blot of 10 ug of rat hippocampal lysate showing specific immunolabeling of the ~78 kDa synapsin I doublet protein.

Immunostaining of 40DIV cultured rat cortical neurons showing punctate labeling of synapsin (Cat. 1926-SYNP, 1:1000, red). The blue is staining nuclear DNA. Cells and photo courtesy of QBMCellScience.

PhosphoSolutions Anti-Synapsin I (100 µL) Antibody

From $164

Mixed neuron-glial cultures stained with CPCA-GAP43 (green) and rabbit antibody to alpha-II spectrin (RPCA-aII-Spec, red), and DNA (blue). The GAP43 antibody stains numerous axonal and dendritic profiles in these cultures, clearly revealing the submembraneous cytoskeleton and vesicles. Photo by Dr. Gerry Shaw, Univ. Florida.

GAP-43 immunoreactivity in a neuroblast within a neurosphere culture. Chicken anti-GAP-43 antibody (1:500 dilution), Fluorescein-goat anti-chicken IgY secondary antibody (Aves Labs, 1:500). Photomicrograph by Hoda Ilias, Aves Labs.

Aves Labs Anti-Growth-Associated Protein-43 (GAP-43) Antibody

$301

Western blot of human T47D cell lysate showing specific immunolabeling of the ~100 kDa CtIP phosphorylated at Thr847 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (λ-Ptase, 1200 units for 30 min).

PhosphoSolutions Anti-CtIP (Thr847) Antibody

From $164

Western blot of rat cortical lysate showing specific immunolabeling of the ~48 kDa, ~65 kDa & ~75 kDa tau isoforms.

Immunostaining of cultured E20 rat cortical neurons and glia stained with anti-TAU antibody (Cat. 1998-TAU, green, 1:2000) and anti-MAP2 (red). The blue is DAPI staining nuclear DNA. Anti-TAU labels perikarya, dendrites, axons of neurons while anti-MAP2 only labels dendrites and perikarya of neurons. Where they overlap they appear orange-yellow.

PhosphoSolutions Anti-Tau Antibody

From $164

Western blot of human striatal lysate showing specific immunolabeling of the ~88 kDa DAT protein.

PhosphoSolutions Anti-Dopamine Transporter, C-Terminus Antibody

From $164

Immunostaining of primary rat cortical neuroepithelial cells with anti-Olig2 (Cat. 1538-OLIG2, red, 1:1000). The cells were treated with basic FGF for 30 hours prior to staining (this induces Olig2 expression in these primary cells).

Western blot of neonatal rat brain lysate showing specific immunolabeling of the ~32 kDa Olig2 protein.

PhosphoSolutions Anti-Olig2 Antibody

From $164

Western blot of 10 µg of rat hippocampal lysate showing specific immunolabeling of the ~180 kDa NR2A subunit of the NMDA receptor.

Immunostaining of rabbit retina showing NR2A in the rod and cone photoreceptors in the outer plexiform layer as well as the entire inner plexiform layer.

PhosphoSolutions Anti-NMDA NR2A Subunit (100 ul) Antibody

From $164

A tissue section through an adult mouse brain showing CNPase (brown staining) in white matter tracts and the granule cell layer of the cerebellum.

CNPase-positive oligodendrocytes (brown) in cerebellar white matter (adult mouse). Right: Western.

Aves Labs Anti-CNPase (Cyclic Nucleotide Phosphodiesterase) Antibody

$481

Beta-Amyloid-positive “neuritic plaque” (shown in higher magnification) in cerebral cortex as seen in a post-mortum specimen taken from an Alzheimer’s disease patient. Picture courtesy of Dr. Randy Woltjer, Oregon Health & Sciences University.

Immunohistochemistry of a capillary showing beta-amyloid peptide in the wall of the vessel. Paraffin-embedded section of a human brain from a patient with diagnosed Alzheimer's Disease. Primary antibody -- 1:500; secondary antibody -- 1:1000 HRP-Goat anti-chicken IgY (Aves Labs). Dr. Randy Woltjer, Dept Pathology, OHSU

Aves Labs Anti-Beta-Amyloid Peptide (N-terminus) Antibody

$481

Biosensis Anti-Neuronal nuclei antigen [NeuN]/FOX3, (NeuN/FOX3) Antibody

$337

Biosensis Anti-Casein, A1 beta Antibody

$417

Western blot image of human TRPM8 in human MDA-MB-231 cells. The blot was probed with rabbit polyclonal anti-TRPM8 (extracellular region) without peptide blocking (lane 1) or with peptide blocking (lane 2).

Immunocytochemical labeling of TRPM8 in paraformaldehyde fixed and NP-40 permeabilized MCF-7 cells. The cells were labeled with rabbit polyclonal anti-TRPM8 (TP5701). The antibody was detected using goat anti-rabbit DyLight® 594.

PhosphoSolutions Anti-TRPM8 (Extracellular region) Antibody

$348

Western blot analysis of C2C12 cells untreated (lanes 1, 3, 5, & 7) or treated with Lambda phosphatase (lanes 2, 4, 6, & 8). The blots were probed with monoclonal anti-MLC20 (clone MY-21) (lanes 1 & 2), polyclonal anti-MLC (Ser-19) phosho-specific (lanes 3 & 4), anti-MLC (Ser-1) phosho-specific (lanes 5 & 6), or anti-MLC (a.a. 11-22) (lanes 7 & 8).

Immunocytochemical labeling of phosphorylated MLC in paraformaldehyde fixed A7r5 cells. The cells were dual-labeled with anti-MLC (MM3441; middle) and anti-MLC (MP4201; top left), anti-MLC (Ser-19) (MP4221; middle left) and anti-MLC (Ser-1) (MP3461; bottom left). Goat anti-Mouse DyLight® 488 and Goat anti-Rabbit DyLight® 594 were used for detection of primary antibodies. The overlay of staining patterns are shown to the right.

PhosphoSolutions Anti-Myosin Light Chain (Ser-19), Phosphospecific Antibody

$348

Western blot of HeLa cell lysates that had been treated with UV (~254 nm) for 0’ or 30’ showing the specific immunolabeling of the ~39 kDa p38 MAPK protein phosphorylated at Thr180/Tyr182.

Immunostaining of human breast cancer tissue showing p38 when phosphorylated at Thr180/Tyr182 (red, 1:250). Photo courtesy of Patsy Ruegg.

PhosphoSolutions Anti-p38 MAPK (Thr180/Tyr182) Antibody

From $164

Western blot of rat cortical lysate showing specific immunolabeling of the ~78 kDa synapsin I phosphorylated at Ser549 in the first lane (-). Phosphospecificity is shown in the second lane (+) where the immunolabeling is completely eliminated by blot treatment with lambda phosphatase (λ-Ptase, 1200 units for 30 minutes).

Immunostaining of cultured mouse caudate neurons showing synapsin I when phosphorylated at Ser549 (Cat. p1560-549, green, 1:500). Cells and photo courtesy of QBMCellScience.

PhosphoSolutions Anti-Synapsin (Ser549) Antibody

From $164

Immunostaining of Chinese Hamster Overy (CHO) cells stably transfected with KV3.1b gene with the phospho-Ser503 Kv3.1 subunit antibody (Cat. p1550-503, green, 1:400). The image on the right shows cells that have been treated with the protein kinase C activator PMA (500nM) while the control cells are on the left.

PhosphoSolutions Anti-Potassium Channel, Voltage-Gated, Kv3.1 Subunit (Ser503) Antibody

From $164

Western blot of wild type (WT) beclin-1 expressed in HeLa cell lysate showing specific immunolabeling of beclin-1 phosphorylated at Ser234. This immunolabeling is decreased in the beclin-1 double alanine substitution mutant (S234A, S295A: Mut) expressed in HeLa cell lysate.

PhosphoSolutions Anti-Beclin1 (Ser234) Antibody

From $164

Western blot of rat cortical lysate showing specific immunolabeling of the ~45 kDa GABAA γ2 protein phosphorylated at Ser327 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is blocked by preadsorption of the phosphopeptide used as the antigen, but not by the corresponding non-phosphopeptide (not shown).

PhosphoSolutions Anti-GABAA Receptor γ2 (Ser327) Antibody

From $164

Western blot of rat striatal lysate showing specific immunolabeling of the ~32 kDa DARPP-32 phosphorylated at Thr34 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (λ-Ptase, 1200 units for 30 min).

Effects of striatal slice treatment with NMDA (25 μM, 5 min), dopamine (DA, 10 μM, 15 min), or both on PKA-dependent phosphorylation of Ser845 GluR1 (top) and Thr34 DARPP-32 (bottom). Image from publication CC-BY-4.0. PMID: 35835216

PhosphoSolutions Anti-DARPP-32 (Thr34) Antibody

From $164

Western blot of mouse whole brain lysate showing specific immunolabeling of the ~46 kDa γ2-subunit of GABAA Receptor.

Immunostaining of mouse retina showing specific labeling of the GABAA-R γ2 subunit (Cat. 832A-GG2C, green, 1:300) and calbindin (red). The blue stain is DAPI staining nuclear DNA. Photo courtesy of Dr. Arlene Hirano, UCLA.

PhosphoSolutions Anti-GABAA Receptor γ2 Antibody

From $164

$Western blot of colchicine treated Sy5y cell lysate showing specific immunolabeling of the ~32 kDa cleaved actin fragment (fractin).$ $Fractin (Cat. 592-FRAC, 1:5000; red) immunostaining of mouse brain signifying the emergence of damaged/dying neurons in entorhinal cortex (EC). Nuclei stained with DAPI (blue). Final image shows fractin+ cells (red) among YFP+ cells (green) at 7 dpi. Image from publication CC-BY-4.0. PMID:36468693$

PhosphoSolutions Anti-Fractin Antibody

From $154

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Polyclonal Antibodies

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