Anti-Presenilin-1 (PS-1) Antibody

Name: Anti-Presenilin-1 (PS-1) Antibody
Brand: Biosensis
SKU: C-1534-500
Price: 347.0 USD
Availability: InStock

Our Anti-Presenilin-1 (PS-1) chicken polyclonal primary antibody detects human, mouse, and rat Presenilin-1 (PS-1), and is affinity-purified. It is validated for use in ELISA, WB.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, WB

Host Species

Chicken

Go to Full Product Details

Data Sheet

SKU: C-1534-500

Volume/Size: 500 µL

Variant

Price:

$347.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Presenilin-1 (PS-1)

Scientific Background

Presenilin-1 (PSEN1) is a multi-pass membrane protein and component of the gamma-secretase complex. PSEN1 is thought to play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may also play a role in hematopoiesis. Defects in PSEN1 are a cause of Alzheimer disease type 3 (AD3), a familial early-onset form of Alzheimer disease (Ref:SWISS-Prot).

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgY

Applications

ELISA, WB

Host Species

Chicken

Immunogen

Mixture of two human Presenilin 1 peptides (311-322 and 341-352 aa). Both sequences are highly conserved in human, mouse and rat.

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.

Physical State

Liquid

Buffer

PBS with 0.02% sodium azide.

Dilution Ranges

WB: 1:1000-1:4000
ELISA: 1:1000-1:4000

Application Details

To minimize background staining, a higher concentration of detergent (such as Tween-20) is suggested in the dilution and washing steps.

Conjugate

Unconjugated

Specificity

Human Presenilin 1.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

ACNINV3; Presenilin 1; FAD; PS-1; Protein S182; PS1; PS1-CTF12; S182; PSEN1; presenilin-1; AD3; presenilin-1 isoform I-467; PSNL1

UniProt ID

P49768
UniProt Summary: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling. Required for normal embryonic brain and skeleton development, and for normal angiogenesis. Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis. Involved in the regulation of neurite outgrowth. Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression.

NCBI Gene ID

5663

Shipping

2-8°C (on cold packs)

Recover password

Create my account

Anti-Presenilin-1 (PS-1) Antibody

SKU: C-1534-500

Product Details

Bulk Order Anti-Presenilin-1 (PS-1) Antibody

Related Products

Recently Viewed