Anti-Presenilin-2 (PS-2) Antibody

Name: Anti-Presenilin-2 (PS-2) Antibody
Brand: Biosensis
SKU: C-1535-500
Price: 347.0 USD
Availability: InStock

Our Anti-Presenilin-2 (PS-2) chicken polyclonal primary antibody detects human, mouse, and rat Presenilin-2 (PS-2), and is affinity-purified. It is validated for use in ELISA, WB.

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, WB

Host Species

Chicken

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Data Sheet

SKU: C-1535-500

Volume/Size: 500 µL

Variant

Price:

$347.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Presenilin-2 (PS-2)

Scientific Background

Presenilin-2 (PSEN2) is a multi-pass membrane protein and component of the gamma-secretase complex. Defects in PSEN2 are a cause of Alzheimer disease type 4 (AD4), an autosomal dominant Alzheimer disease. (Ref:SWISS-Prot).

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgY

Applications

ELISA, WB

Host Species

Chicken

Immunogen

Mixture of two human Presenilin 2 peptides (319-330 and 349-360 aa). Both sequences are highly conserved in human, mouse and rat.

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.

Physical State

Liquid

Buffer

PBS with 0.02% sodium azide.

Dilution Ranges

WB: 1:1000-1:4000
ELISA: 1:1000-1:4000

Application Details

To minimize background staining, a higher concentration of detergent (such as Tween-20) is suggested in the dilution and washing steps.

Conjugate

Unconjugated

Specificity

Human Presenilin 2.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

AD3L; AD3LP; CMD1V; AD5; PS2; E5-1; STM2; STM-2; presenilin-2; PSEN2; AD4; Alzheimer disease 4; PSNL2; PS-2

UniProt ID

P49810
UniProt Summary: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.

NCBI Gene ID

5664

Shipping

2-8°C (on cold packs)

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Anti-Presenilin-2 (PS-2) Antibody

SKU: C-1535-500

Product Details

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