Anti-Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Antibody

Name: Anti-Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Antibody
Brand: Biosensis
SKU: C-1533-100
Price: 347.0 USD
Availability: InStock

Our Anti-Peroxisome proliferator-activated receptor gamma (PPAR-gamma) chicken polyclonal primary antibody detects human Peroxisome proliferator-activated receptor gamma (PPAR-gamma), and is affinity-purified. It is validated for use in WB.

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Species Reactivity

Human

Applications

Host Species

Chicken

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Data Sheet

SKU: C-1533-100

Volume/Size: 100 µL

Variant

Price:

$347.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Peroxisome proliferator-activated receptor gamma (PPAR-gamma)

Scientific Background

Peroxisome proliferator-activated receptor gamma (PPARG) is a nuclear hormone receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription (Ref: SWISSPROT).

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgY

Applications

Host Species

Chicken

Immunogen

Human Peroxisome proliferator-activated receptor gamma peptide (115-129 aa).

Immunogen Species

Human

Species Reactivity

Human

Storage

Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.

Physical State

Liquid

Buffer

PBS with 0.02% sodium azide.

Dilution Ranges

ELISA: 1:2000-1:5000

Conjugate

Unconjugated

Specificity

Human Peroxisome proliferator-activated receptor gamma.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

CIMT1; PPAR gamma; NR1C3; PPAR-gamma; PPARG1; Nuclear receptor subfamily 1 group C member 3; PPARG2; PPARG; PPARgamma; peroxisome proliferator-activated receptor gamma

UniProt ID

P37231
UniProt Summary: Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism, glucose homeostasis and beta-oxidation of fatty acids. Activated by lipid ligands: binds peroxisome proliferators, such as hypolipidemic drugs, and fatty acids, such as prostaglandin J2 metabolites. Ligand-binding results in a conformational change in the receptor, promoting dissociation of repressors and recruitment of coactivators, and subsequent activation of target gene expression. Specifically binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels.

NCBI Gene ID

5468

Shipping

2-8°C (on cold packs)

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Anti-Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Antibody

SKU: C-1533-100

Product Details

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