Anti-Shank3 Antibody FL650 Conjugate (N367/62)

Name: Anti-Shank3 Antibody FL650 Conjugate
Brand: NeuroMab
SKU: 75-344-FL650
Price: 543.0 USD
Availability: InStock

Our mouse Shank3 FL650 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N367/62. It detects mouse and rat Shank3 and is purified by Protein A chromatography. KO validated. Works in IHC, ICC.

Anti-Shank3 Antibody FL650 Conjugate

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Species Reactivity

Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

Biotin

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-344-FL650

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Shank3

Scientific Background

SH3 and multiple ankyrin repeat domains protein 3, or shank 3 (also known as proline-rich synapse-associated protein 2 (ProSAP2)) is a member of the shank family. Shank 3 binding domains include a SH3 domain, a proline rich domain, a PDZ domain and ankyrin repeat domains. Shank 3 is found in many tissues including heart and spleen, but is most abundantly expressed in brain at the post synaptic density. Shank 3 acts as a scaffold protein anchoring and connecting membrane bound receptors, ion channels and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 3 may play a role in synapse formation and dendritic spine maturation. Mutations in the Shank 3 gene have been associated with neuropsychiatric diseases, including autism spectrm disorder.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N367/62

Isotype

IgG2a

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Shank3 Prosap2

Molecular Weight

190 kDa

Immunogen

Fusion protein amino acids 538-626 (SH3 domain) of rat Shank3 (accession number Q9JLU4) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2940171

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

Specificity

Does not cross-react with Shank1 or Shank2

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)

UniProt ID

Q9JLU4

Shipping

Shipped on ice packs

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Anti-Shank3 Antibody FL650 Conjugate (N367/62)

SKU: 75-344-FL650

Product Details

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