Anti-Shank3 Antibody (N367/62)
Our Anti-Shank3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N367/62. It detects mouse and rat Shank3, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
Distribution of SHANK3 immuno-positive cells in different regions of the adult mouse cerebral cortex. N, O: High-magnification views of SHANK3-positive cells in the RSPV region (N) and hippocampal region (O) as shown in image M. Green, SHANK3-positive cells (Cat no 75-344, 1:200); blue, cell nuclei. Scale bars, 300 μm (M); 100 μm (N, O). Image from publication, CC-BY-4.0. PMID: 39693031.
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Ships: 1-2 business days
Product Specific References for Applications and Species
- Electron Microscopy: Rat
- Immunocytochemistry: Rat
- Immunohistochemistry: Mouse | Non-Human Primate
- Immunoprecipitation: Mouse
- Western Blot: Mouse | Rat
| Electron Microscopy: Rat | ||
| PMID | Dilution | Publication |
| 27144302 | 1:250 | Tao-Cheng, J.H., et al. 2016. Zinc stabilizes Shank3 at the postsynaptic density of hippocampal synapses. PLoS One, e0153979. |
| Immunocytochemistry: Rat | ||
| PMID | Dilution | Publication |
| 30524232 | 1:100 | Ha, H.T., et al. 2018. Shank and zinc mediate an AMPA receptor subunit switch in developing neurons. Frontiers in Molecular Neuroscience, 405. |
| 26547831 | 1:400 | MacGillavry, H.D., et al. 2016. Shank-cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapses.. European Journal of Neuroscience, 179-193. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 39693031 | 1:200 | Yang, J, et al. 2024. Deciphering the Role of Shank3 in Dendritic Morphology and Synaptic Function Across Postnatal Developmental Stages in the Shank3B KO Mouse. Neuroscience Bulletin, . |
| Immunohistochemistry: Non-Human Primate | ||
| PMID | Dilution | Publication |
| 31189958 | 1:100 | Zhou, Y., et al. 2019. Atypical behaviour and connectivity in SHANK3-mutant macaques. Nature , 326-331. |
| Immunoprecipitation: Mouse | ||
| PMID | Dilution | Publication |
| 34852231 | not listed | Lautz, J.D., et al. 2021. Synaptic protein interaction networks encode experience by assuming stimulus-specific and brain-region-specific states. Cell Reports, 110076. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 39693031 | 1:200 | Yang, J, et al. 2024. Deciphering the Role of Shank3 in Dendritic Morphology and Synaptic Function Across Postnatal Developmental Stages in the Shank3B KO Mouse. Neuroscience Bulletin, . |
| 38297084 | 1:1000 | Stamenkovic, V, et al. 2024. SRC family kinase inhibition rescues molecular and behavioral phenotypes, but not protein interaction network dynamics, in a mouse model of Fragile X syndrome. Molecular Psychiatry, 1392-1405. |
| 37925173 | 1:500 | Cao, Q, et al. 2023. Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model. Aging, 11697-11719. |
| 36587867 | not listed | Liu, P., et al. 2022. Degradation of Perineuronal Nets in the Cerebellar Interpositus Nucleus Ameliorated Social Deficits in Shank3-deficient Mice. Neuroscience, 29-38. |
| 35022531 | 1:1000 | Tzanoulinou, S., et al. 2022. Inhibition of Trpv4 rescues circuit and social deficits unmasked by acute inflammatory response in a Shank3 mouse model of Autism. . Molecular Psychiatry, 2080-2094. |
| 33229412 | not listed | Pandian, S., et al. 2020. Myosin va brain-specific mutation alters mouse behavior and disrupts hippocampal synapses. eNeuro, . |
| 32019829 | 1:2000 | Perfitt, T.L., et al. 2020. Neuronal L-type calcium channel signaling to the nucleus requires a novel CaMKIIα-Shank3 interaction. Journal of Neuroscience, 2000-2014. |
| 31602784 | 1:500 | Rein, B., et al. 2020. Diminished social interaction incentive contributes to social deficits in mouse models of autism spectrum disorder. Genes, Brain, and Behavior, e12610. |
| 31332372 | not listed | Guo, B., et al. 2019. Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice. Nature Neuroscience, 1223-1234. |
| 30302388 | not listed | Drapeau, E., et al. 2018. Behavioral phenotyping of an improved mouse model of Phelan–McDermid syndrome with a complete deletion of the Shank3 gene. eNeuro, . |
| 29531362 | 1:500 | Qin, L., et al. 2018. Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition. Nature Neuroscience, 564-574. |
| 26687841 | not listed | Zhou, Y., et al. 2016. Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.. Neuron, 147-162. |
| 26627310 | 1:500 | Berg, J.M., et al. 2015. JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.. Neuron, 1173-1191. |
| Western Blot: Rat | ||
| PMID | Dilution | Publication |
| 30524232 | 1:100 | Ha, H.T., et al. 2018. Shank and zinc mediate an AMPA receptor subunit switch in developing neurons. Frontiers in Molecular Neuroscience, 405. |
| 28139198 | 1:500 | Harony-Nicolas, H., et al. 2017. Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat.. Elife, e18904. |
| 24089484 | 1:500 | Duffney, L.J., et al. 2013. Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism.. Journal of Neuroscience, 15767-15778. |