Anti-Shank3 Antibody FL594 Conjugate (N367/62)

Name: Anti-Shank3 Antibody FL594 Conjugate
Brand: NeuroMab
SKU: 75-344-FL594
Price: 499.0 USD
Availability: InStock

from NeuroMab Datasheet

Available Conjugates

Unconjugated

490

550

650

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N367/62

Applications

ICC, IHC

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

Shank3 Prosap2

Molecular Weight

190 kDa

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Volume: 200 µL

Variant

Price:

$499

Quantity:

Bulk Order Anti-Shank3 Antibody FL594 Conjugate

Product Details

Target

Shank3

Target Description

SH3 and multiple ankyrin repeat domains protein 3, or shank 3 (also known as proline-rich synapse-associated protein 2 (ProSAP2)) is a member of the shank family. Shank 3 binding domains include a SH3 domain, a proline rich domain, a PDZ domain and ankyrin repeat domains. Shank 3 is found in many tissues including heart and spleen, but is most abundantly expressed in brain at the post synaptic density. Shank 3 acts as a scaffold protein anchoring and connecting membrane bound receptors, ion channels and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 3 may play a role in synapse formation and dendritic spine maturation. Mutations in the Shank 3 gene have been associated with neuropsychiatric diseases, including autism spectrm disorder.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N367/62

Isotype

IgG2a

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Shank3 Prosap2

Molecular Weight

190 kDa

Antigen

Fusion protein amino acids 538-626 (SH3 domain) of rat Shank3 (accession number Q9JLU4) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2940170

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

Specificity

Does not cross-react with Shank1 or Shank2

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)

UniProt Details

UniProt (Human): Q9BYB0
UniProt (Immunogen Species): Q9JLU4

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Anti-Shank3 Antibody FL594 Conjugate (N367/62)

Available Conjugates

Anti-Shank3 Antibody FL594 Conjugate
SKU: 75-344-FL594

Bulk Order Anti-Shank3 Antibody FL594 Conjugate

Product Details

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Anti-Shank3 Antibody FL594 Conjugate (N367/62)

Available Conjugates

Anti-Shank3 Antibody FL594 Conjugate SKU: 75-344-FL594

Bulk Order Anti-Shank3 Antibody FL594 Conjugate

Product Details

Anti-Shank3 Antibody FL594 Conjugate
SKU: 75-344-FL594