Anti-Epithelial Cell Adhesion Molecule (Ep-CAM) Antibody FL490 Conjugate (ESA 214)

Name: Anti-Epithelial Cell Adhesion Molecule (Ep-CAM) Antibody FL490 Conjugate
Brand: Antibodies Incorporated
SKU: MM-1014-FL490
Price: 486.0 USD
Availability: InStock

Our mouse Epithelial Cell Adhesion Molecule FL490 conjugate monoclonal antibody from Antibodies Incorporated is produced in-house from clone ESA 214. It detects human Epithelial Cell Adhesion Molecule and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-Epithelial Cell Adhesion Molecule (Ep-CAM) Antibody FL490 Conjugate

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Species Reactivity

Human

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: MM-1014-FL490

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Epithelial Cell Adhesion Molecule

Scientific Background

Epithelial specific antigen is a transmembrane glycoprotein (40 kDa) also known as ESA or epithelial cellular adhesion molecule (Ep-CAM). This protein is expressed on basolateral cell surface in most simple epithelia and vast majority of cancers. According to the “Cancer Stem Cells” (CSC) theory, tumors are not viewed as simple monoclonal expression of transformed cells, but rather as complex tissue where abnormal growth is driven by a minority pathological CSC pool that on one hand has acquired tumor related features such as uncontrolled growth and ability to form metasis and on the other hand maintains its inherent capacity to self renew and differentiate into a phenotypic ally heterogeneous, although aberrant progency. This antibody has been used recently to characterize the EpCAM high CD44+ versus EpCAM low/Cd44- indifferent cancer cells.

Format

Purified by Protein A Chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

ESA 214

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

EPCAM

Molecular Weight

40 kDa

Immunogen

Small cell lung carcinoma

Immunogen Species

Human

Species Reactivity

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used in Western blot.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Ep-CAM; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1

UniProt ID

P16422

Shipping

Shipped on ice packs

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Anti-Epithelial Cell Adhesion Molecule (Ep-CAM) Antibody FL490 Conjugate (ESA 214)

SKU: MM-1014-FL490

Product Details

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