Anti-Vitronectin Antibody (HV23)

Name: Anti-Vitronectin Antibody
Brand: Antibodies Incorporated
SKU: CSI 003-23-010
Price: 325.0 USD
Availability: InStock

Our mouse Vitronectin monoclonal antibody from Antibodies Incorporated is produced in-house from clone HV23. It detects canine, feline, goat, horse, and human Vitronectin and is Protein A or Protein G purified. Works in ELISA, WB.

Anti-Vitronectin Antibody

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Species Reactivity

Canine, Feline, Goat, Horse, Human

Applications

ELISA, WB

Host Species

Mouse

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Data Sheet

SKU: CSI 003-23-010

Volume: 100 uL

Variant

Price:

$325.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Vitronectin

Scientific Background

Vitronectin is a plasma glycoprotein that circulates in the blood. Vitronectin is circulating as a mixture of both 75 kDa and 65 kDa forms. Vitronectin is a major cell adhesive glycoprotein and is a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins and is often involved in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin and also its integrin receptor recognizes fibronectin. (2)

Format

Protein A or Protein G purified

Concentration

1 mg/mL ±15%

Clonality

Monoclonal

Clone

HV23

Isotype

IgG1/k

Applications

ELISA, WB

Host Species

Mouse

Gene Name

VTN

Molecular Weight

65 kDa, 75 kDA

Immunogen

Human vitronectin purified from plasma by heparin-affinity chromatography

Immunogen Species

Human

Species Reactivity

Canine, Feline, Goat, Horse, Human

Storage

2-8°C without exposure to light

Physical State

Liquid

Production Notes

BSA free

Buffer

0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Dilution Ranges

WB: 1:50-1:200

Application Details

CSI 003-23 also binds to vitronectin in ELISA when vitronectin is coated directly onto the microtiter well. In Western blotting a dilution guideline of 1/50 and 1/200 has proved successful. (1,2)

Conjugate

Unconjugated

Specificity

CSI 003-23 is highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin). CSI 003-23 binds nearly as well to native vitronectin as to denatured. CSI 003-23 is a potent inhibitor of integrin-mediated cell adhesion to vitronectin and a moderate inhibitor of PAI-1 binding. Epitope is located in the somatomedin B domain

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

VTN, V75, VN, VNT, vitronectin, complement S-protein, epibolin, serum spreading factor, somatomedin B

UniProt ID

P04004

NCBI Gene ID

7448

Shipping

Shipped on ice packs

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Anti-Vitronectin Antibody (HV23)

SKU: CSI 003-23-010

Product Details

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