Anti-Tyrosine Hydroxylase Antibody (Ascites) (LNC1)

Name: Anti-Tyrosine Hydroxylase Antibody (Ascites)
Brand: Antibodies Incorporated
SKU: 76-700
Price: 394.0 USD
Availability: InStock

Our mouse Tyrosine Hydroxylase (TH) monoclonal antibody from Antibodies Incorporated is produced in-house from clone LNC1. It detects chicken, frog, human, lizard, monkey, mouse, rat, vole, and zebrafish Tyrosine Hydroxylase (TH) and is ascites fluid. Works in WB, IHC, ICC, IP, ELISA.

Western Blot of HEK293 cells transfected to express human Tyrosine Hydroxylase isoform 2 and Green Fluorescent Protein demonstrates the specificity of mouse monoclonal antibody LNC1 to tyrosine hydroxylase protein.

LNC1 anti-TH monoclonal antibody was used at 2.5ug/mL to stain endogenous tyrosine hydroxylase in rat brain lysate.

Tyrosine Hydroxylase

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Species Reactivity

Chicken, Frog, Human, Lizard, Mouse, Non-Human Primate, Rat, Vole, Zebrafish

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

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Data Sheet

Trial Size

SKU: 76-700

Volume: 100 µL

Variant

Price:

$394.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Tyrosine 3-monooxygenase

Scientific Background

TH is the rate-limiting enzyme in the synthesis of the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine and is responsible for converting L-tyrosine to L-dopa. Synthesis of catecholamines is regulated by the interaction of TH with its’ cofactor, tetrahydrobiopterin (BH4) and the substrates L-tyrosine and molecular oxygen. In humans four TH mRNA splice variants (hTH1-hTH4) have been isolated while subprimate species rely on a single form of TH. It is known that the hTH1-hTH4 variants are identical in their catalytic domain but differ in their N-terminal regulatory domains. Importantly, LNC1 reacts with the catalytic domain of TH and thus with all four isoforms of human TH. The role of TH in the synthesis of catecholamine neurotransmitters suggests a connection between the enzyme and a number of neuropathogenic diseases characterized by irregular catecholamine levels, such as Parkinson's disease, schizophrenia, and dystonia, as well as a variety of cardiovascular diseases.

Format

Ascites

Clonality

Monoclonal

Clone

LNC1

Isotype

IgG1

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

TH, TYH, EC 1.14.16.2

Molecular Weight

59-63 kDa

Immunogen

Tyrosine Hydroxylase purified from PC12 cells

Species Reactivity

Chicken, Frog, Human, Lizard, Mouse, Non-Human Primate, Rat, Vole, Zebrafish

Antibody Registry ID

AB_2940724

Physical State

Liquid

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe rat brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Synonyms

Dystonia 14; Tyrosine 3-monooxygenase; DYT14; DYT5b; EC 1.14.16.2; OTTHUMP00000011225; OTTHUMP00000011226; ple; Protein Pale; TH; The; TY3H_HUMAN; TYH; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; Tyrosine hydroxylase

UniProt ID

P07101
UniProt Summary: Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa. In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity. Positively regulates the regression of retinal hyaloid vessels during postnatal development.

NCBI Gene ID

7054

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Anti-Tyrosine Hydroxylase Antibody (Ascites) (LNC1)

SKU: 76-700

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