Anti-OCRL/INPP5b Antibody FL650 Conjugate (N166A/26)

Name: Anti-OCRL/INPP5b Antibody FL650 Conjugate
Brand: NeuroMab
SKU: 75-215-FL650
Price: 486.0 USD
Availability: InStock

Our mouse OCRL/INPP5b FL650 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N166A/26. It detects human, mouse, and rat OCRL/INPP5b and is purified by Protein A chromatography. Works in ICC.

Anti-OCRL/INPP5b Antibody FL650 Conjugate

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ICC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

Biotin

Carrier-Free

Go to Full Product Details

Data Sheet

SKU: 75-215-FL650

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

OCRL/INPP5b

Scientific Background

Inositol polyphosphate 5-phosphatase B is encoded by the gene INPP5B. INPP5B is a member of the inositol 1,4,5-triphosphate 5-phosphatase family. INPP5B functions in the regulation of calcium signaling by inactivating inositol phosphates. INPP5B is expressed highest in the urinary bladder. Diseases associated with INPP5B include dent disease 2, lowe oculocerebrorenal syndrome, charcot-marie-tooth disease type 4j, dent disease 1, and frontotemporal dementia and/or amyotrophic lateral sclerosis 2.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N166A/26

Isotype

IgG1

Applications

ICC

Host Species

Mouse

Gene Name

INPP5B OCRL2

Molecular Weight

100 kDa

Immunogen

Fusion protein amino acids 1-901 (full-length) of human OCRL (accession number Q01968) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939799

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

Specificity

Cross-reacts with INPP5b

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

INPP5F; Type II inositol 1,4,5-trisphosphate 5-phosphatase; NPHL2; EC 3.1.3.36; OCRL-1; 75 kDa inositol polyphosphate-5-phosphatase; OCRL1; Phosphoinositide 5-phosphatase; inositol polyphosphate 5-phosphatase OCRL-1; 5PTase; Lowe oculocerebrorenal syndrome protein; oculocerebrorenal syndrome of Lowe; phosphatidylinositol polyphosphate 5-phosphatase

UniProt ID

Q01968
UniProt Summary: Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling.

NCBI Gene ID

4952

Shipping

Shipped on ice packs

Fluorophore Data and Guidelines: Download

Recover password

Create my account

Anti-OCRL/INPP5b Antibody FL650 Conjugate (N166A/26)

SKU: 75-215-FL650

Product Details

Bulk Order Anti-OCRL/INPP5b Antibody FL650 Conjugate

Related Products

Recently Viewed