Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged Kv2.1, GFP-tagged OCRL or RFP-tagged INPP5b plasmids and probed with N166A/26 (left) and another cross-reacting mouse OCRL antibody (right).
Inositol polyphosphate 5-phosphatase B is encoded by the gene INPP5B. INPP5B is a member of the inositol 1,4,5-triphosphate 5-phosphatase family. INPP5B functions in the regulation of calcium signaling by inactivating inositol phosphates. INPP5B is expressed highest in the urinary bladder. Diseases associated with INPP5B include dent disease 2, lowe oculocerebrorenal syndrome, charcot-marie-tooth disease type 4j, dent disease 1, and frontotemporal dementia and/or amyotrophic lateral sclerosis 2.
Fusion protein amino acids 1-901 (full-length) of human OCRL (also known as OCRL1, Lowe oculocerebrorenal syndrome protein, Inositol polyphosphate 5-phosphatase and INPP5f, accession number Q01968); Rat: 93% identity (845/904 amino acids identical); Mouse: 91% identity (824/901 amino acids identical); Greater than 50% identity with INPP5b
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Cross-reacts with INPP5b
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 184.108.40.206) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)
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