Anti-OCRL/INPP5b Antibody (N166A/26)

Name: Anti-OCRL/INPP5b Antibody
Brand: NeuroMab
SKU: 75-215
Price: 329.0 USD
Availability: InStock

Our Anti-OCRL/INPP5b mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N166A/26. It detects human, mouse, and rat OCRL/INPP5b, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged Kv2.1, GFP-tagged OCRL or RFP-tagged INPP5b plasmids and probed with N166A/26 (left) and another cross-reacting mouse OCRL antibody (right).

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-215

Volume: 100 µL

Variant

Price:

$329.00

Quantity:

Ships: 1-2 business days

Product Details

Target

OCRL/INPP5b

Target Description

Inositol polyphosphate 5-phosphatase B is encoded by the gene INPP5B. INPP5B is a member of the inositol 1,4,5-triphosphate 5-phosphatase family. INPP5B functions in the regulation of calcium signaling by inactivating inositol phosphates. INPP5B is expressed highest in the urinary bladder. Diseases associated with INPP5B include dent disease 2, lowe oculocerebrorenal syndrome, charcot-marie-tooth disease type 4j, dent disease 1, and frontotemporal dementia and/or amyotrophic lateral sclerosis 2.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N166A/26

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

INPP5B OCRL2

Molecular Weight

100 kDa

Antigen

Fusion protein amino acids 1-901 (full-length) of human OCRL (accession number Q01968) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2156491

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Cross-reacts with INPP5b

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)

UniProt ID

Q01968

Product Specific References for Applications and Species

Immunocytochemistry: Human | Mouse
Western Blot: Human | Mouse
Additional Publications: Unspecified

Immunocytochemistry: Human
PMID	Dilution	Publication
22543976	not listed	Luo, N., et al. 2012. OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome. Human Molecular Genetics, 3333-3344.

Immunocytochemistry: Mouse
PMID	Dilution	Publication
33987909	not listed	Wang, B., et al. 2021 . OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring. EMBO Reports, e52173.

Western Blot: Human
PMID	Dilution	Publication
22543976	not listed	Luo, N., et al. 2012. OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome. Human Molecular Genetics, 3333-3344.

Western Blot: Mouse
PMID	Dilution	Publication
33987909	not listed	Wang, B., et al. 2021 . OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring. EMBO Reports, e52173.

Additional Publications: Unspecified
PMID	Publication
27060558	Clasadonte, J., et al. 2016. Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy. Neurobiology of Disease, 315-325.

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Anti-OCRL/INPP5b Antibody (N166A/26)

SKU: 75-215

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-OCRL/INPP5b Antibody

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