Anti-Neuroligin-1 Antibody Biotin Conjugate (N97A/31)

Name: Anti-Neuroligin-1 Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-160-BTN
Price: 543.0 USD
Availability: InStock

Our mouse Neuroligin-1 biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N97A/31. It detects chicken, mouse, and rat Neuroligin-1 and is purified by Protein A chromatography. KO validated. Works in ELISA, IHC, ICC, WB.

Anti-Neuroligin-1 Antibody Biotin Conjugate

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Species Reactivity

Chicken, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-160-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Neuroligin-1

Scientific Background

Neuroligin 1 is a member of a large family of alternatively sliced proteins located at the post synaptic surface in the central nervous system, and stains as a post synaptic marker. Neuroligin 1 is involved in cell-cell-interactions by binding to neurexin family members and other postsynaptic proteins to localize receptors and channels in the postsynaptic density. Suggested roles for Neuroligin 1 include synapse function and synaptic signal transmission and maintaining synapse integrity. Mutations in Neuroligans have been implicated in autism and other cognitive disorders.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N97A/31

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Nlgn1

Molecular Weight

120 kDa

Immunogen

Fusion Protein Amino acids 718-843 (intracellular C-terminus) of rat Neuroligin-1 (accession number NP_446320) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Chicken, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

Does not cross-react with Neuroligin-2, -3, -4 or -4*

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

neuroligin-1; Neuroligin I

UniProt ID

Q62765
UniProt Summary: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. The protein is involved in nervous system development.

NCBI Gene ID

116647

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Anti-Neuroligin-1 Antibody Biotin Conjugate (N97A/31)

SKU: 75-160-BTN

Product Details

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