Anti-Homer1L Antibody (L113/27)

Name: Anti-Homer1L Antibody
Brand: NeuroMab
SKU: 75-453
Price: 337.0 USD
Availability: InStock

Our mouse Homer1L monoclonal antibody from NeuroMab is produced in-house from clone L113/27. It detects human, mouse, and rat Homer1L and is purified by Protein A chromatography. Works in IHC, ICC, ELISA.

Adult rat hippocampus immunohistochemistry.

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-453

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Homer1L

Scientific Background

Homer Scaffold Protein 1 is encoded by the gene HOMER1. Homer1 is a member of the Homer family of dendritic proteins. Homer1 is a postsynaptic density scaffolding protein which binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1, and SHANK3. HOMER1 is expressed in the skeletal muscle, heart, and brain. Diseases associated with HOMER1 include Phelan-Mcdermid Syndrome, bipolar disorder, autism, fragile x syndrome, and pervasive developmental disorder.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L113/27

Isotype

IgG2b

Applications

ELISA, ICC, IHC

Host Species

Mouse

Gene Name

Homer1 Vesl1

Molecular Weight

45-55 kDa

Immunogen

Fusion protein amino acids 121-363 (C-terminus) of mouse Homer1L (accession number Q9Z2Y3) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2651166

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

Supernatant is provided in cell culture medium with 0.1% sodium azide as anti-microbial

Conjugate

Unconjugated

Specificity

Does not cross-react with Homer1S

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

PSD-Zip45; Homer protein homolog 1; Ves-1; Homer-1; VASP/Ena-related gene up-regulated during seizure and LTP 1; vesl-1; homer homolog 1; homer; neuronal immediate early gene; immediate early gene protein Homer1A

UniProt ID

Q9Z2Y3
UniProt Summary: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 5 counteracts the effects by competing for binding sites. Isoform 3 regulates the trafficking and surface expression of GRM5. Isoform 5 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, isoform 2 and isoform 3 to regulate synaptic metabotropic glutamate function. Isoform 5, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.

NCBI Gene ID

26556

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Anti-Homer1L Antibody (L113/27)

SKU: 75-453

Product Details

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