Anti-GAD65/67 Antibody FL550 Conjugate (L127/12)

Name: Anti-GAD65/67 Antibody FL550 Conjugate
Brand: NeuroMab
SKU: 75-508-FL550
Price: 486.0 USD
Availability: InStock

Our mouse GAD65/67 FL550 conjugate monoclonal antibody from NeuroMab is produced in-house from clone L127/12. It detects human, mouse, and rat GAD65/67 and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-GAD65/67 Antibody FL550 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-508-FL550

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GAD65/67

Scientific Background

There are two forms of the enzyme glutamic-acid decarboxylase (GAD), a 65-kDa form (GAD65) and a 67-kDa form (GAD67) which are the result of the expression of different genes. Further splicing of GAD 67 produces one or two smaller variants, including GAD25 and GAD44. GAD67 and GAD65 are expressed in adult brain and the pancreas. The truncated forms GAD25 and GAD44 are expressed during embryonic development. Glutamic acid decarboxylase enzyme functions to catalyze the production of gamma-aminobutyric acid from L-glutamic acid.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

L127/12

Isotype

IgG2a

Applications

ICC, IHC

Host Species

Mouse

Gene Name

GAD1, GAD, GAD67

Molecular Weight

70 kDa

Immunogen

Fusion protein amino acids 1-594 (full-length) of human GAD67 (accession number Q99259) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2940693

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

Cross-reacts with GAD25, GAD44 and GAD65/GAD2

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

CPSQ1; GAD67; SCP; glutamate decarboxylase 1; 67 kDa glutamic acid decarboxylase; GAD-67; glutamate decarboxylase 1 (brain; 67kDa; glutamate decarboxylase 67 kDa isoform; GAD1; GAD and DCE1

UniProt ID

Q99259
UniProt Summary: Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.

NCBI Gene ID

2571

Shipping

Shipped on ice packs

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Anti-GAD65/67 Antibody FL550 Conjugate (L127/12)

SKU: 75-508-FL550

Product Details

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