Anti-GAD65/67 Antibody (L127/12)

Name: Anti-GAD65/67 Antibody
Brand: NeuroMab
SKU: 75-508
Price: 285.0 USD
Availability: InStock

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This antibody reacts with an epitope common to GAD67(GAD1), GAD65/GAD2, GAD25, and GAD44.

Clonality

Monoclonal

Applications

AT, ICC, IHC, WB

Host Species

Mouse

Molecular Weight

70 kDa

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Product Details

Target Description

There are two forms of the enzyme glutamic-acid decarboxylase (GAD), a 65-kDa form (GAD65) and a 67-kDa form (GAD67) which are the result of the expression of different genes. Further splicing of GAD 67 produces one or two smaller variants, including GAD25 and GAD44. GAD67 and GAD65 are expressed in adult brain and the pancreas. The truncated forms GAD25 and GAD44 are expressed during embryonic development. Glutamic acid decarboxylase enzyme functions to catalyze the production of gamma-aminobutyric acid from L-glutamic acid.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L127/12

Isotype

IgG2a

Applications

AT, ICC, IHC, WB

Host Species

Mouse

Molecular Weight

70 kDa

Antigen

Fusion protein amino acids 1-594 (full-length) of human GAD67 (also known as Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD and DCE1, accession number Q99259); Mouse: 97% identity (577/594 amino acids identical); Rat: 97% identity (577/594 amino acids identical); 100% identity (213/213 amino acids identical) with GAD25; >90% identity (366/391 amino acids identical, highest in N-terminus) with GAD44; >60% identity (375/569 amino acids identical, highest in C-terminus) with GAD2/GAD65/DCE2

Species Reactivity

Human, Mouse, Rat

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Conjugate

Unconjugated

Specificity

Cross-reacts with GAD25, GAD44 and GAD65/GAD2

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

GAD67, Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD and DCE1

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Anti-GAD65/67 Antibody (L127/12)

This antibody reacts with an epitope common to GAD67(GAD1), GAD65/GAD2, GAD25, and GAD44.

Anti-GAD65/67 Antibody
SKU: 75-508

Product Details

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Anti-GAD65/67 Antibody (L127/12)

This antibody reacts with an epitope common to GAD67(GAD1), GAD65/GAD2, GAD25, and GAD44.

Anti-GAD65/67 Antibody SKU: 75-508

Product Details

Anti-GAD65/67 Antibody
SKU: 75-508