There are two forms of the enzyme glutamic-acid decarboxylase (GAD), a 65-kDa form (GAD65) and a 67-kDa form (GAD67) which are the result of the expression of different genes. Further splicing of GAD 67 produces one or two smaller variants, including GAD25 and GAD44. GAD67 and GAD65 are expressed in adult brain and the pancreas. The truncated forms GAD25 and GAD44 are expressed during embryonic development. Glutamic acid decarboxylase enzyme functions to catalyze the production of gamma-aminobutyric acid from L-glutamic acid.
AT, ICC, IHC, WB
Fusion protein amino acids 1-594 (full-length) of human GAD67 (also known as Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD and DCE1, accession number Q99259); Mouse: 97% identity (577/594 amino acids identical); Rat: 97% identity (577/594 amino acids identical); 100% identity (213/213 amino acids identical) with GAD25; >90% identity (366/391 amino acids identical, highest in N-terminus) with GAD44; >60% identity (375/569 amino acids identical, highest in C-terminus) with GAD2/GAD65/DCE2
Human, Mouse, Rat
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