Anti-Cavbeta4 Ca2+ Channel Antibody (N10/7)

Name: Anti-Cavbeta4 Ca2+ Channel Antibody
Brand: NeuroMab
SKU: 75-054
Price: 337.0 USD
Availability: InStock

Our mouse Cavbeta4 Ca2+ channel monoclonal antibody from NeuroMab is produced in-house from clone N10/7. It detects human, mouse, pig, and rat Cavbeta4 Ca2+ channel and is purified by Protein A chromatography. Works in WB, IHC, ICC, IP, ELISA.

Immunoblot on adult rat brain membrane (RBM), and adult mouse brain membranes (MBM) from wild-type (WT) and lethargic (lh/lh) mice (left) Lethargic mice courtesy of Dr. Jeff Noebels, Baylor College of Medicine.

Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].

Adult rat hippocampus immunohistochemistry.

Adult rat hippocampus immunohistochemistry. (Higher magnification view of CA1.)

Immunoblot on adult rat brain membrane (RBM), and adult mouse brain membranes (MBM) from wild-type (WT) and lethargic (lh/lh) mice (left) Lethargic mice courtesy of Dr. Jeff Noebels, Baylor College of Medicine.

Click on image to zoom

Species Reactivity

Human, Mouse, Pig, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-054

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Cavbeta4 Ca2+ channel

Scientific Background

Voltage-dependent L-type calcium channel subunit beta-4 or Cav ß4 is encoded by the gene CACNB4. Cavß4 is a cytoplasmic subunit of voltage-sensitive calcium channels.These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cav ß4 is expressed predominantly in the brain (cerebellum) and kidney. Diseases associated with this gene include Episodic Ataxia, Type 5 and Epilepsy.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N10/7

Isotype

IgG1

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Cacnb4 Cacnlb4

Molecular Weight

50 kDa

Immunogen

Synthetic peptide amino acids 458-474 of rat Cav4 (DENYHNERARKSRNRLS; accession number D4A055)

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Pig, Rat

Antibody Registry ID

AB_2069776

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:500
IHC: 1:500
ICC: 1:500

Conjugate

Unconjugated

Specificity

No cross-reactivity against rat Cavβ1b, Cavβ2a, and Cavβ3 in transfected cells

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

CAB4; Voltage-dependent L-type calcium channel subunit beta-4; calcium channel beta 4 subunit; calcium channel voltage-dependent subunit beta 4; calcium channel; voltage-dependent; beta 4 subunit

UniProt ID

D4A055
UniProt Summary: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

NCBI Gene ID

58942

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Anti-Cavbeta4 Ca2+ Channel Antibody (N10/7)

SKU: 75-054

Product Details

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