Anti-Notch1 Antibody (BSA and Azide free) (N253/32)

Name: Anti-Notch1 Antibody (BSA and Azide free)
Brand: NeuroMab
SKU: 75-295-CF
Price: 486.0 USD
Availability: InStock

Our mouse Notch1 carrier-free monoclonal antibody from NeuroMab is produced in-house from clone N253/32. It detects mouse and rat Notch1 and is purified by Protein A chromatography. Works in WB, ICC, ELISA.

Anti-Notch1 Antibody (BSA and Azide free)

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Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Biotin

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Data Sheet

SKU: 75-295-CF

Volume: 100 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Notch1

Scientific Background

Notch Receptor 1 is encoded by the gene NOTCH1. NOTCH1 is a member of the NOTCH family. NOTCH1 is involved in processes related to cell fate specification, differentiation, proliferation, and survival. NOTCH1 is highly expressed in the brain, lungs, and thymus. Diseases associated with NOTCH1 include Aortic Valve Disease 1 and Adams-Oliver Syndrome 5.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.6-1.0 mg/mL

Clonality

Monoclonal

Clone

N253/32

Isotype

IgG1

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

Notch1 Motch

Molecular Weight

>270 kDa, ~120 kDa and smaller fragments (due to proteolysis)

Immunogen

Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1 (accession number Q01705) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and buffer exchanged into 1X PBS. Purified mAbs are >90% specific antibody.

Buffer

PBS

Conjugate

Unconjugated

Specificity

Does not cross-react with Notch2 or Notch3

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Neurogenic locus notch homolog protein 1 (Notch 1) (Motch A) (mT14) (p300) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]

UniProt ID

Q01705

Shipping

Shipped on ice packs

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Anti-Notch1 Antibody (BSA and Azide free) (N253/32)

SKU: 75-295-CF

Product Details

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