Anti-Notch1 Antibody (N253/32)

Name: Anti-Notch1 Antibody
Brand: NeuroMab
SKU: 75-295
Price: 285.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

ICC, WB

Host Species

Mouse

Gene Name

Notch1 Motch

Molecular Weight

>270 kDa, ~120 kDa and smaller fragments (due to proteolysis)

Go to Full Product Details

$Immunoblot against adult rat brain membrane (RBM) or low- speed pellet (RBLSP) fractions denatured at 95oC for 5 min or 37oC for 15 min and probed with N253/32 (left) and K58/35 (right) TC supe.$

Immunoblot against adult rat brain membrane (RBM) or low- speed pellet (RBLSP) fractions denatured at 95oC for 5 min or 37oC for 15 min and probed with N253/32 (left) and K58/35 (right) TC supe.

$Immunoblot against adult rat brain membrane (RBM) or low- speed pellet (RBLSP) fractions denatured at 95oC for 5 min or 37oC for 15 min and probed with N253/32 (left) and K58/35 (right) TC supe.$

Product Details

Target

Neurogenic locus notch homolog protein 1 (Notch 1) (Motch A) (mT14) (p300) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]

Target Description

Notch Receptor 1 is encoded by the gene NOTCH1. NOTCH1 is a member of the NOTCH family. NOTCH1 is involved in processes related to cell fate specification, differentiation, proliferation, and survival. NOTCH1 is highly expressed in the brain, lungs, and thymus. Diseases associated with NOTCH1 include Aortic Valve Disease 1 and Adams-Oliver Syndrome 5.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N253/32

Antibody Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

Notch1 Motch

Molecular Weight

>270 kDa, ~120 kDa and smaller fragments (due to proteolysis)

Antigen

Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1 (also known as Neurogenic locus notch homolog protein 1, hN1, Translocationassociated notch protein, TAN-1, Motch A, mT14, p300 and Motch, accession number Q01705) Rat: 93% identity (185/197 amino acids identical) Human: 84% identity (166/197 amino acids identical) ~40% identity with Notch2, Notch3 and Notch4

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2315898

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Conjugate

Unconjugated

Specificity

Does not cross-react with Notch2 or Notch3

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Neurogenic locus notch homolog protein 1 (Notch 1) (Motch A) (mT14) (p300) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]

UniProt Details

UniProt (Human): P46531
UniProt (Immunogen Species): Q01705

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Anti-Notch1 Antibody (N253/32)

Anti-Notch1 Antibody
SKU: 75-295

Product Details

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Anti-Notch1 Antibody (N253/32)

Anti-Notch1 Antibody SKU: 75-295

Product Details

Anti-Notch1 Antibody
SKU: 75-295