Anti-Notch1 Antibody (N253/32)

Name: Anti-Notch1 Antibody
Brand: NeuroMab
SKU: 75-295
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N253/32

Applications

ICC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

Notch1 Motch

Molecular Weight

>270 kDa, ~120 kDa and smaller fragments (due to proteolysis)

Go to Full Product Details

$Immunoblot against adult rat brain membrane (RBM) or low- speed pellet (RBLSP) fractions denatured at 95oC for 5 min or 37oC for 15 min and probed with N253/32 (left) and K58/35 (right) TC supe.$

Immunoblot against adult rat brain membrane (RBM) or low- speed pellet (RBLSP) fractions denatured at 95oC for 5 min or 37oC for 15 min and probed with N253/32 (left) and K58/35 (right) TC supe.

$Immunoblot against adult rat brain membrane (RBM) or low- speed pellet (RBLSP) fractions denatured at 95oC for 5 min or 37oC for 15 min and probed with N253/32 (left) and K58/35 (right) TC supe.$

Volume: 100 µL

Variant

Price:

$308

Quantity:

Bulk Order Anti-Notch1 Antibody

Product Details

Target

Notch1

Target Description

Notch Receptor 1 is encoded by the gene NOTCH1. NOTCH1 is a member of the NOTCH family. NOTCH1 is involved in processes related to cell fate specification, differentiation, proliferation, and survival. NOTCH1 is highly expressed in the brain, lungs, and thymus. Diseases associated with NOTCH1 include Aortic Valve Disease 1 and Adams-Oliver Syndrome 5.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N253/32

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

Notch1 Motch

Molecular Weight

>270 kDa, ~120 kDa and smaller fragments (due to proteolysis)

Antigen

Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1 (accession number Q01705) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2315898

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with Notch2 or Notch3

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Neurogenic locus notch homolog protein 1 (Notch 1) (Motch A) (mT14) (p300) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]

UniProt Details

UniProt (Human): P46531
UniProt (Immunogen Species): Q01705

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Anti-Notch1 Antibody (N253/32)

Available Conjugates

Anti-Notch1 Antibody
SKU: 75-295

Bulk Order Anti-Notch1 Antibody

Product Details

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Anti-Notch1 Antibody (N253/32)

Available Conjugates

Anti-Notch1 Antibody SKU: 75-295

Bulk Order Anti-Notch1 Antibody

Product Details

Anti-Notch1 Antibody
SKU: 75-295