Anti-Nav1.6 Na+ Channel Antibody (K87A/10)

Name: Anti-Nav1.6 Na+ Channel Antibody
Brand: NeuroMab
SKU: 75-026
Price: 394.0 USD
Availability: InStock

Our mouse Nav1.6 Na+ channel monoclonal antibody from NeuroMab is produced in-house from clone K87A/10. It detects feline, human, mouse, and rat Nav1.6 Na+ channel and is purified by Protein A chromatography. KO validated. Works in IHC, ICC, IP, ELISA.

Adult rat optic nerve immunofluorescence staining K87A/10=red Rabbit anti-Caspr=green Image courtesy of Dr. Matthew Rasband (Baylor College of Medicine).

(Closeup) Adult rat optic nerve immunofluorescence staining K87A/10=red Rabbit anti-Caspr=green Image courtesy of Dr. Matthew Rasband (Baylor College of Medicine).

Cerebellar granule cells, 16 days in culture, obtained from wild-type (WT) and Nav1.6-null “Null” mice. K87A/10=green. DAPI=blue. Scale bar = 20 μm. Images courtesy of Drs. L. M. Sharkey and M. H. Meisler, University of Michigan School of Medicine.

Adult rat optic nerve immunofluorescence staining K87A/10=red Rabbit anti-Caspr=green Image courtesy of Dr. Matthew Rasband (Baylor College of Medicine).

Click on image to zoom

Species Reactivity

Feline, Human, Mouse, Rat

Applications

ELISA, ICC, IHC, IP

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

Go to Full Product Details

Data Sheet

KO Validated

SKU: 75-026

Volume: 100 µL

Variant

Price:

$394.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Nav1.6 Na+ channel

Scientific Background

Nav1.6 Na+ channel (sodium channel, voltage-gated, type 8, alpha subunit/ SCN8A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn8a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.6 Na+ channel is located at the nodes of Ranvier. It heavily participates in the regulation of nerve conduction velocity. It has been shown that Nav1.6 Na+ channel loss in roddents induces paralysis due to the failure of the neuromuscular junction (Wagnon et al., 2016).

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K87A/10

Isotype

IgG1

Applications

ELISA, ICC, IHC, IP

Host Species

Mouse

Gene Name

Scn8a

Molecular Weight

<200 kDa

Immunogen

Synthetic peptide 459-476 (intracellular interdomain loop I-II) of rat Nav1.6 (accession number O88420)

Immunogen Species

Rat

Species Reactivity

Feline, Human, Mouse, Rat

Antibody Registry ID

AB_2184197

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

IHC: 1:250
ICC: 1:250

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Sodium channel protein type 8 subunit alpha (Peripheral nerve protein type 4) (PN4) (Sodium channel 6) (NaCh6) (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)

UniProt ID

O88420

Shipping

Shipped on ice packs

Recover password

Create my account

Anti-Nav1.6 Na+ Channel Antibody (K87A/10)

SKU: 75-026

Product Details

Bulk Order Anti-Nav1.6 Na+ Channel Antibody

Related Products

Recently Viewed