Our mouse Nav1.2 Na+ channel FL594 conjugate monoclonal antibody from NeuroMab is produced in-house from clone K69/3. It detects feline, human, mouse, non-human primate, and rat Nav1.2 Na+ channel and is purified by Protein A chromatography. Works in IHC, ICC.
Nav1.2 Na+ channel (sodium channel, voltage-gated, type II, alpha subunit/ SCN2A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn2a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.1 Na+ channel is a sodium selective channel that maintains Na+ homeostasis by allowing Na+ ions to pass in accordance of their electrochemical gradient.Nav1.2 Na+ channel is implicated in the regulation of hippocampal replay, whose waves ripples (SPW-R) condition memories. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several cases of seizures, autism and bipolar disorders.
Purified by Protein A chromatography
Lot dependent: provided at 0.3-0.5 mg/mL
Monoclonal
K69/3
IgG2a
ICC, IHC
Mouse
Scn2a Scn2a1
˜250 kDa
Fusion protein amino acids 1882-2005 (cytoplasmic C-terminus) of rat rat Nav1.2 (accession number P04775) produced recombinantly in E. Coli
Rat
Feline, Human, Mouse, Non-Human Primate, Rat
AB_2939158
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL594 Ex: 594 nm, Em: 615 nm
Lack of cross-reactivity against Nav1.1, Nav1.3, Nav1.6 verified
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
12 months from date of receipt
Sodium channel protein type 2 subunit alpha (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2)
