Primary Antibody
Feline, Human, Mouse, Non-Human Primate, Rat
K69/3
ICC, IHC, WB
Mouse
Purified by Protein A chromatography
Scn2a Scn2a1
˜250 kDa
![Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with K69/3 (left) or N52A/42 (right) TC supe.](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-024-k69-3-wb-1_{width}x.jpg?v=1626902879)
Adult rat whole brain immunohistochemistry.
![Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with K69/3 (left) or N52A/42 (right) TC supe.](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-024-k69-3-wb-1_1024x.jpg?v=1626902879)
- Yin L, Rasch MJ, He Q, Wu S, Dou F, Shu Y. (2017), 'Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron..' Cereb Cortex. 10.1093/cercor/bhv245.
- Bosch MK, Nerbonne JM, Townsend RR, Miyazaki H, Nukina N, Ornitz DM, Marionneau C. (2016), 'Proteomic analysis of native cerebellar iFGF14 complexes..' Channels (Austin).. 10.1080/19336950.2016.1153203.
- Hamada MS, Kole MH. (2015), 'Myelin loss and axonal ion channel adaptations associated with gray matter neuronal hyperexcitability..' Journal of Neuroscience. 10.1523/JNEUROSCI.4747-14.2015.
- Wildburger NC, Ali SR, Hsu WC, Shavkunov AS, Nenov MN, Lichti CF, LeDuc RD, Mostovenko E, Panova-Elektronova NI, Emmett MR, Nilsson CL, Laezza F. (2015), 'Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain..' Molecular & Cellular Proteomics. 10.1074/mcp.M114.040055.
- Wimmer VC, Harty RC, Richards KL, Phillips AM, Miyazaki H, Nukina N, Petrou S. (2015), 'Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain..' Journal of Comparative Neurology. 10.1002/cne.23715.
- Gazina EV, Leaw BT, Richards KL, Wimmer VC, Kim TH, Aumann TD, Featherby TJ, Churilov L, Hammond VE, Reid CA, Petrou S. (2015), 'Neonatal'' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour..' Human Molecular Genetics. 10.1093/hmg/ddu562.
- Li T, Tian C, Scalmani P, Frassoni C, Mantegazza M, Wang Y, Yang M, Wu S, Shu Y. (2014), 'Action potential initiation in neocortical inhibitory interneurons..' PLoS Biology. 10.1371/journal.pbio.1001944.
- Wang X, Hooks BM, Sun QQ. (2014), 'Thorough GABAergic innervation of the entire axon initial segment revealed by an optogenetic ''laserspritzer''..' The Journal of Physiology. 10.1113/jphysiol.2014.275719.
- Tian C, Wang K, Ke W, Guo H, Shu Y. (2014), 'Molecular identity of axonal sodium channels in human cortical pyramidal cells..' Frontiers in Neuroscience. 10.3389/fncel.2014.00297.
- Baek JH, Rubinstein M, Scheuer T, Trimmer JS. (2014), 'Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures..' The Journal of Biological Chemistry. 10.1074/jbc.M114.562785.
- Liu W, Deng J, Wang G, Zhang C, Luo X, Yan D, Su Q, Liu J. (2014), 'KCNE2 modulates cardiac L-type Ca(2+) channel..' Journal of Molecular and Cellular Cardiology. 10.1016/j.yjmcc.2014.03.013.
- Vega AV, Avila G, Matthews G. (2013), 'Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression..' Scientific Reports. 10.1038/srep02809.
- He YL, Liu DD, Fang YJ, Zhan XQ, Yao JJ, Mei YA. (2013), 'Exposure to extremely low-frequency electromagnetic fields modulates Na+ currents in rat cerebellar granule cells through increase of AA/PGE2 and EP receptor-mediated cAMP/PKA pathway..' PLoS One. 10.1371/journal.pone.0054376.
- Martínez-Hernández J, Ballesteros-Merino C, Fernández-Alacid L, Nicolau JC, Aguado C, Luján R. (2013), 'Polarised localisation of the voltage-gated sodium channel Na(v)1.2 in cerebellar granule cells..' The Cerebellum. 10.1007/s12311-012-0387-1.
- Huang CY, Chu D, Hwang WC, Tsaur ML. (2012), 'Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain..' Journal of Comparative Neurology. 10.1002/cne.23119.
- Dhaunchak AS, Becker C, Schulman H, De Faria O Jr, Rajasekharan S, Banwell B, Colman DR, Bar-Or A; Canadian Pediatric Demyelinating Disease Group. (2012), 'Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis..' Annals of Neurology. 10.1002/ana.22693.
- Wykes R, Kalmbach A, Eliava M, Waters J. (2012), 'Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice..' Neurobiology of Aging. 10.1016/j.neurobiolaging.2011.05.001.
- Kaphzan H, Buffington SA, Jung JI, Rasband MN, Klann E. (2011), 'Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome..' Journal of Neuroscience. 10.1523/JNEUROSCI.4162-11.2011.
- Ahn HS, Black JA, Zhao P, Tyrrell L, Waxman SG, Dib-Hajj SD. (2011), 'Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons..' Molecular Pain. 10.1186/1744-8069-7-32.
- Barry J, Gu Y, Gu C. (2010), 'Polarized targeting of L1-CAM regulates axonal and dendritic bundling in vitro..' European Journal of Neuroscience. 10.1111/j.1460-9568.2010.07447.x.
- Wimmer VC, Reid CA, Mitchell S, Richards KL, Scaf BB, Leaw BT, Hill EL, Royeck M, Horstmann MT, Cromer BA, Davies PJ, Xu R, Lerche H, Berkovic SF, Beck H, Petrou S. (2010), 'Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus..' Journal of Clinical Investigation. 10.1172/JCI42219.
- Lorincz A, Nusser Z. (2010), 'Molecular identity of dendritic voltage-gated sodium channels..' Science. 10.1126/science.1187958.
- Wimmer VC, Reid CA, So EY, Berkovic SF, Petrou S. (2010), 'Axon initial segment dysfunction in epilepsy..' The Journal of Physiology. 10.1113/jphysiol.2010.188417.
- Liao Y, Deprez L, Maljevic S, Pitsch J, Claes L, Hristova D, Jordanova A, Ala-Mello S, Bellan-Koch A, Blazevic D, Schubert S, Thomas EA, Petrou S, Becker AJ, De Jonghe P, Lerche H. (2010), 'Molecular correlates of age-dependent seizures in an inherited neonatal-infantile epilepsy..' Brain. 10.1093/brain/awq057.
- Black JA, Newcombe J, Waxman SG. (2010), 'Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5..' Brain. 10.1093/brain/awq003.
- Brackenbury WJ, Calhoun JD, Chen C, Miyazaki H, Nukina N, Oyama F, Ranscht B, Isom LL (2010), 'Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth..' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.0909434107.
- Berendt FJ, Park KS, Trimmer JS. (2010), 'Multisite phosphorylation of voltage-gated sodium channel alpha subunits from rat brain..' Journal of Proteome Research. 10.1021/pr901171q.
- Bouvier D, Tremblay ME, Riad M, Corera AT, Gingras D, Horn KE, Fotouhi M, Girard M, Murai KK, Kennedy TE, McPherson PS, Pasquale EB, Fon EA, Doucet G. (2010), 'EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain..' Journal of Neurochemistry. 10.1111/j.1471-4159.2010.06582.x.
- Conant K, Wang Y, Szklarczyk A, Dudak A, Mattson MP, Lim ST. (2010), 'Matrix metalloproteinase-dependent shedding of intercellular adhesion molecule-5 occurs with long-term potentiation..' Neuroscience. 10.1016/j.neuroscience.2009.12.061.
- Merrick EC, Kalmar CL, Snyder SL, Cusdin FS, Yu EJ, Sando JJ, Isakson BE, Jackson AP, Patel MK. (2010), 'The importance of serine 161 in the sodium channel beta3 subunit for modulation of Na(V)1.2 gating..' Pflügers Archiv: European Journal of Physiology. 10.1007/s00424-009-0739-y.
- Kress GJ, Dowling MJ, Eisenman LN, Mennerick S. (2010), 'Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons..' Hippocampus. 10.1002/hipo.20667.
- Crawford DK, Mangiardi M, Xia X, López-Valdés HE, Tiwari-Woodruff SK. (2009), 'Functional recovery of callosal axons following demyelination: a critical window..' Neuroscience. 10.1016/j.neuroscience.2009.09.069.
- Thomas EA, Hawkins RJ, Richards KL, Xu R, Gazina EV, Petrou S. (2009), 'Heat opens axon initial segment sodium channels: a febrile seizure mechanism?.' Annals of Neurology. 10.1002/ana.21712.
- von Reyn CR, Spaethling JM, Mesfin MN, Ma M, Neumar RW, Smith DH, Siman R, Meaney DF. (2009), 'Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit..' Journal of Neuroscience. 10.1523/JNEUROSCI.2339-09.2009.
- O''Malley HA, Shreiner AB, Chen GH, Huffnagle GB, Isom LL. (2009), 'Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis..' Molecular and Cellular Neuroscience. 10.1016/j.mcn.2008.10.001.
- Lonigro A, Devaux JJ. (2009), 'Disruption of neurofascin and gliomedin at nodes of Ranvier precedes demyelination in experimental allergic neuritis..' Brain. 10.1093/brain/awn281.
- Mojumder DK, Wensel TG, Frishman LJ. (2008), 'Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina..' Molecular Vision. .
- Zhao P, Barr TP, Hou Q, Dib-Hajj SD, Black JA, Albrecht PJ, Petersen K, Eisenberg E, Wymer JP, Rice FL, Waxman SG. (2008), 'Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: evidence for a role in pain..' Pain. 10.1016/j.pain.2008.03.016.
- Mojumder DK, Frishman LJ, Otteson DC, Sherry DM. (2007), 'Voltage-gated sodium channel alpha-subunits Na(v)1.1, Na(v)1.2, and Na(v)1.6 in the distal mammalian retina..' Molecular Vision. .