Anti-Nav1.2 Na+ Channel Antibody (BSA and Azide free) (K69/3)

Name: Anti-Nav1.2 Na+ Channel Antibody (BSA and Azide free)
Brand: NeuroMab
SKU: 75-024-CF
Price: 486.0 USD
Availability: InStock

Our mouse Nav1.2 Na+ channel carrier-free monoclonal antibody from NeuroMab is produced in-house from clone K69/3. It detects feline, human, mouse, non-human primate, and rat Nav1.2 Na+ channel and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Anti-Nav1.2 Na+ Channel Antibody (BSA and Azide free)

Click on image to zoom

Species Reactivity

Feline, Human, Mouse, Non-Human Primate, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Biotin

Go to Full Product Details

Data Sheet

SKU: 75-024-CF

Volume: 100 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Nav1.2 Na+ channel

Scientific Background

Nav1.2 Na+ channel (sodium channel, voltage-gated, type II, alpha subunit/ SCN2A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn2a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.1 Na+ channel is a sodium selective channel that maintains Na+ homeostasis by allowing Na+ ions to pass in accordance of their electrochemical gradient.Nav1.2 Na+ channel is implicated in the regulation of hippocampal replay, whose waves ripples (SPW-R) condition memories. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several cases of seizures, autism and bipolar disorders.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.6-1.0 mg/mL

Clonality

Monoclonal

Clone

K69/3

Isotype

IgG2a

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Scn2a Scn2a1

Molecular Weight

˜250 kDa

Immunogen

Fusion protein amino acids 1882-2005 (cytoplasmic C-terminus) of rat rat Nav1.2 (accession number P04775) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Feline, Human, Mouse, Non-Human Primate, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and buffer exchanged into 1X PBS. Purified mAbs are >90% specific antibody.

Buffer

PBS

Conjugate

Unconjugated

Specificity

Lack of cross-reactivity against Nav1.1, Nav1.3, Nav1.6 verified

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

NachII; Sodium channel protein type 2 subunit alpha; RII/RIIA; Sodium channel protein brain II subunit alpha; RNSCPIIR; Sodium channel protein type II subunit alpha; SCN; Voltage-gated sodium channel subunit alpha Nav1.2; Scn2a1; Scn2a2; ScpII; RIIA sodium channel protein; sodium channel protein; brain II subunit alpha; sodium channel; voltage-gated; type II; alpha 1

UniProt ID

P04775
UniProt Summary: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory.

NCBI Gene ID

24766

Shipping

Shipped on ice packs

Recover password

Create my account

Anti-Nav1.2 Na+ Channel Antibody (BSA and Azide free) (K69/3)

SKU: 75-024-CF

Product Details

Bulk Order Anti-Nav1.2 Na+ Channel Antibody (BSA and Azide free)

Related Products

Recently Viewed