Anti-Nav1.1 Na+ Channel Antibody Biotin Conjugate (K74/71)

Name: Anti-Nav1.1 Na+ Channel Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-023-BTN
Price: 543.0 USD
Availability: InStock

Our mouse Nav1.1 Na+ channel biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone K74/71. It detects human, mouse, non-human primate, and rat Nav1.1 Na+ channel and is purified by Protein A chromatography. Works in ELISA, IHC, ICC, WB, IP.

Anti-Nav1.1 Na+ Channel Antibody Biotin Conjugate

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Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

Trial Size

SKU: 75-023-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Nav1.1 Na+ channel

Scientific Background

Nav1.1 Na+ channel (sodium channel, voltage-gated, type I, alpha subunit/ SCN1A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn1a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.1 Na+ channel is a sodium selective channel that maintains Na+ homeostasis by allowing Na+ ions to pass in accordance of their electrochemical gradient. The protein plays an important role in the release of neurotransmittors from the neurons. Therefore, Nav1.1 Na+ channel is involved in the perception of mechanical pain due to the activation of sematosensory neurons without the involvement of inflammation. Mutation of the gene encoding for Nav1.1 Na+ channel is one of the main cause of epilepsy and febrile seizures.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

K74/71

Isotype

IgG1

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Scn1a

Molecular Weight

220 kDa

Immunogen

Fusion Protein Amino acids 1929-2009 (cytoplasmic C-terminus) of rat Nav1.1 (accession number P04774) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity with Nav1.2, Nav1.3 and Nav1.6

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)

UniProt ID

P04774

Shipping

Shipped on ice packs

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Anti-Nav1.1 Na+ Channel Antibody Biotin Conjugate (K74/71)

SKU: 75-023-BTN

Product Details

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