Anti-Nav1.1 Na+ Channel Antibody FL490 Conjugate (K74/71)

Name: Anti-Nav1.1 Na+ Channel Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-023-FL490
Price: 499.0 USD
Availability: InStock

from NeuroMab Datasheet

Available Conjugates

Unconjugated

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Clone

K74/71

Applications

ICC, IHC

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

Scn1a

Molecular Weight

220 kDa

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Volume: 200 µL

Variant

Price:

$499

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Bulk Order Anti-Nav1.1 Na+ Channel Antibody FL490 Conjugate

Product Details

Target

Nav1.1 Na+ channel

Target Description

Nav1.1 Na+ channel (sodium channel, voltage-gated, type I, alpha subunit/ SCN1A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn1a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.1 Na+ channel is a sodium selective channel that maintains Na+ homeostasis by allowing Na+ ions to pass in accordance of their electrochemical gradient. The protein plays an important role in the release of neurotransmittors from the neurons. Therefore, Nav1.1 Na+ channel is involved in the perception of mechanical pain due to the activation of sematosensory neurons without the involvement of inflammation. Mutation of the gene encoding for Nav1.1 Na+ channel is one of the main cause of epilepsy and febrile seizures.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

K74/71

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Scn1a

Molecular Weight

220 kDa

Antigen

Fusion protein amino acids 1929-2009 (cytoplasmic C-terminus) of rat Nav1.1 (accession number P04774) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_2939152

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity with Nav1.2, Nav1.3 and Nav1.6

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)

UniProt Details

UniProt (Human): P35498
UniProt (Immunogen Species): P04774

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Anti-Nav1.1 Na+ Channel Antibody FL490 Conjugate (K74/71)

Available Conjugates

Anti-Nav1.1 Na+ Channel Antibody FL490 Conjugate
SKU: 75-023-FL490

Bulk Order Anti-Nav1.1 Na+ Channel Antibody FL490 Conjugate

Product Details

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Anti-Nav1.1 Na+ Channel Antibody FL490 Conjugate (K74/71)

Available Conjugates

Anti-Nav1.1 Na+ Channel Antibody FL490 Conjugate SKU: 75-023-FL490

Bulk Order Anti-Nav1.1 Na+ Channel Antibody FL490 Conjugate

Product Details

Anti-Nav1.1 Na+ Channel Antibody FL490 Conjugate
SKU: 75-023-FL490