Anti-Kv3.1B K+ Channel Antibody (N16B/8)

Name: Anti-Kv3.1B K+ Channel Antibody
Brand: NeuroMab
SKU: 75-041
Price: 394.0 USD
Availability: InStock

Our mouse Kv3.1b K+ channel monoclonal antibody from NeuroMab is produced in-house from clone N16B/8. It detects hamster, human, non-human primate, mouse, and rat Kv3.1b K+ channel and is purified by Protein A chromatography. Works in WB, IHC, ICC, IP, ELISA.

Adult rat hippocampus immunohistochemistry.

Fluorescence images showing the specific lableling of Kv 3.1 (Cat. 75-041) identifying Ascl1SA6/Bcl2 mouse cortical glia converting into induced neurons. Image provided by publication. PMID: 39454007

Immunoblot versus adult rat brain membranes (RBM), and adult mouse hippocampal membranes (MBM) from Kv3.1/Kv3.3 double knockout and WT mice (mouse samples courtesy of Dr. Rolf Joho).

Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].

Adult rat hippocampus immunohistochemistry.

Click on image to zoom

Species Reactivity

Hamster, Human, Mouse, Non-Human Primate, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-041

Volume: 100 µL

Variant

Price:

$394.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Kv3.1b K+ channel

Scientific Background

Potassium voltage-gated channel subfamily C member 1, or Kv3.1b is encoded by the gene KCNC1. Kv3.1 is a member of the Shaw subfamily of voltage gated potassium channels. Kv3.1b is expressed in many parts of the brain including the cerebellum, globus pallidus, subthalamic nucleus, substantia nigra, cortical and hippocampal in neurons at presynaptic membranes. It is also expressed in retinal ganglion cells and muscle and testis tissues. It is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Its function is important in repolarization of action potentials and is expressed in neurons that execute repetitive high frequency firing. Alterations in expression are associated with certain types of epilepsy, spinocerebellar ataxia, unverricht-lundborg syndrome and demyelinating diseases.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N16B/8

Isotype

IgG1

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnc1

Molecular Weight

110 kDa

Immunogen

Fusion protein amino acids 437-585 (cytoplasmic C-terminus) of rat Kv3.1b (accession number P25122) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Hamster, Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_2131480

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000
ICC: 1:250

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Potassium voltage-gated channel subfamily C member 1 (NGK2) (RAW2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)

UniProt ID

P25122

Shipping

Shipped on ice packs

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Anti-Kv3.1B K+ Channel Antibody (N16B/8)

SKU: 75-041

Product Details

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