Our mouse Kv1.2 K+ channel FL490 conjugate monoclonal antibody from NeuroMab is produced in-house from clone K14/16. It detects gerbil, human, mouse, non-human primate, rat, Xenopus, and zebrafish Kv1.2 K+ channel and is purified by Protein A chromatography. KO validated. Works in IHC, ICC.
Anti-Kv1.2 K+ Channel Antibody FL490 Conjugate
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Gerbil, Human, Mouse, Non-Human Primate, Rat, Xenopus, Zebrafish
Kv1.2 K+ channel (Potassium voltage-gated channel subfamily A member 2), which is encoded by KCNA2 gene, is part of the Potassium voltage-gated channel family. Kv1.2 K+ channel switches between its open and closed conformation in response to the voltage difference across the membrane, which selectively allows the traffic of K+. Kv1.2 K+ channel determines potassium ion permeability of excitable membranes according to their electrochemical gradient. Therefore, this protein has for function to regulate neurotransmitter release, neuronal excitability, smooth muscle contraction, heart muscle contraction or insulin secretion. Kv1.2 is recognized as a tansmembrane/ multi-pass membrane protein. Anti-Kv1.2 K+ channel K14/16 is often used in IHC on human normal cerebral cortex.
Purified by Protein A chromatography
Lot dependent: provided at 0.3-0.5 mg/mL
Monoclonal
K14/16
IgG2b
ICC, IHC
Mouse
KCNA2
80 kDa
Fusion protein amino acids 428-499 (cytoplasmic C-terminus) of human Kv1.2 (accession number P63142) produced recombinantly in E. Coli
Human
Gerbil, Human, Mouse, Non-Human Primate, Rat, Xenopus, Zebrafish
AB_2939092
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL490 Ex: 491 nm, Em: 515 nm
No cross-reactivity against Kv1.1, Kv1.3, Kv1.4, Kv1.5 and Kv1.6 expressed in transfected cells
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
KO Validated