Anti-Kv1.2 K+ Channel Antibody (K14/16)

Name: Anti-Kv1.2 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-008
Price: 345.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated Trial Size

177 Citations

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

K14/16

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Format

Purified

Gene Name

KCNA2

Molecular Weight

80 kDa

Go to Full Product Details

Adult rat hippocampus immunohistochemistry.

Immunoblot on brain membranes from wild-type (WT) and Kv1.2 knockout (Kv1.2-/-) mice and from adult rat brain (RBM).

Immunoblot on membranes from whole rat (RBM) and mouse (MBM) brain and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

Price:

$345

Quantity:

Bulk Order Anti-Kv1.2 K+ Channel Antibody

Product Details

Target

Kv1.2 K+ channel

Target Description

Kv1.2 K+ channel (Potassium voltage-gated channel subfamily A member 2), which is encoded by KCNA2 gene, is part of the Potassium voltage-gated channel family. Kv1.2 K+ channel switches between its open and closed conformation in response to the voltage difference across the membrane, which selectively allows the traffic of K+. Kv1.2 K+ channel determines potassium ion permeability of excitable membranes according to their electrochemical gradient. Therefore, this protein has for function to regulate neurotransmitter release, neuronal excitability, smooth muscle contraction, heart muscle contraction or insulin secretion. Kv1.2 is recognized as a tansmembrane/ multi-pass membrane protein. Anti-Kv1.2 K+ channel K14/16 is often used in IHC on human normal cerebral cortex.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K14/16

Isotype

IgG2b

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

KCNA2

Molecular Weight

80 kDa

Antigen

Fusion protein amino acids 428-499(cytoplasmic C-terminus) of rat Kv1.2 (accession number P63142), Epitope mapped to within amino acids 463-480; Human: 100% identity; Mouse: 100% identity

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2296313

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against Kv1.1, Kv1.3, Kv1.4, Kv1.5 and Kv1.6 expressed in transfected cells

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium voltage-gated channel subfamily A member 2 (NGK1) (Voltage-gated K(+) channel HuKIV) (Voltage-gated potassium channel HBK5) (Voltage-gated potassium channel subunit Kv1.2)

UniProt Details

UniProt (Human): P16389
UniProt (Immunogen Species): P16389

Product Specific References for Applications and Species

Gene Expression Assay: Mouse
Immunocytochemistry: Mouse | Rat
Immunohistochemistry: Human | Mouse | Rat
Western Blot: Human | Mouse | Rat
Additional Publications: Unspecified

Gene Expression Assay: Mouse
PMID	Dilution	Publication
28673977	not listed	Seagar, M., et al. 2017. LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels. PNAS, 7719-24.

Immunocytochemistry: Mouse
PMID	Dilution	Publication
31164806	not listed	Bonetto, G., et al. 2019. Selective axonal expression of the Kv1 channel complex in pre-myelinated GABAergic hippocampal neurons. Frontiers in Cellular Neuroscience, 222.
30224722	1:500	Yang, Y.M., et al. 2018. Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain.. Molecular Psychiatry, 2017-35.
29429934	not listed	Dawes, J.M., et al. 2018. Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability. . Neuron, 806-822.
29138759	not listed	Browne, L., et al. 2017. Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea.. eNeuro, ENEURO.0303-17.2017.
28331203	1:100	Rama, S., et al. 2017. The role of axonal Kv1 channels in CA3 pyramidal cell excitability. Scientific Reports, 315.
25362471	not listed	Chang, K.J., et al. 2014. Glial ankyrins facilitate paranodal axoglial junction assembly.. Nature Neuroscience, 1673-81.
24412576	not listed	Barry, J., et al. 2014. Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons.. Developmental Cell, 117-31.
24011083	1:200	Green, J.A., et al. 2014. Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons.. BMC Neuroscience, 96.

Immunocytochemistry: Rat
PMID	Dilution	Publication
33185190	1:100	Sanders, S.S., et al. 2020. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. eLife, e56058.
31176559	1:100	Saint-Martin, M., et al. 2019. Impact of anti-CASPR2 autoantibodies from patients with autoimmune encephalitis on CASPR2/TAG-1 interaction and Kv1 expression. Journal of Autoimmunity, 102284.
30598502	not listed	Hivert, B., et al. 2019. ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment. . Journal of Cell Science, jcs219774.

Immunohistochemistry: Human
PMID	Dilution	Publication
33315860	1:100	Gallego-Delgado, P., et al. 2020. Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier. PLoS Biology, e3001008.
29564531	not listed	Willis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. Brain Structure and Function, 2663-71.
28115470	not listed	Lang, B., et al. 2017. Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies. Journal of Neurology, Neurosurgery, and Psychiatry, 353-61.

Immunohistochemistry: Mouse
PMID	Dilution	Publication
35726031	1:200	Malara, M., et al. 2022. SHANK3 Deficiency Leads to Myelin Defects in the Central and Peripheral Nervous System. Cellular and Molecular Life Sciences, 371.
35501931	not listed	Radomski, K.L., et al. 2022. Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury. Acta Neuropathologica Communications, 67.
33397712	not listed	Sukhanov, N., et al. 2021. Differential Contribution of Cadm1–Cadm3 Cell Adhesion Molecules to Peripheral Myelinated Axons. Journal of Neuroscience, 1393-1400.
32142125	not listed	Kawamura, A., et al. 2020. Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice. Human Molecular Genetics, 1274-91.
32052742	1:500	Liu, C.H., et al. 2020. Nodal β spectrins are required to maintain Na + channel clustering and axon integrity. eLife, e52378.
31248728	1:250	Zheng, Y., et al. 2019. Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties. . Neuron, 598-616.
31164806	not listed	Bonetto, G., et al. 2019. Selective axonal expression of the Kv1 channel complex in pre-myelinated GABAergic hippocampal neurons. Frontiers in Cellular Neuroscience, 222.
30447021	1:200	Saifetiarova, J., et al. 2019. Ablation of Cytoskeletal Scaffolding Proteins, Band 4.1B and Whirlin, Leads to Cerebellar Purkinje Axon Pathology and Motor Dysfunction. Journal of Neuroscience Research, 313-31.
29300891	1:400	Scott, R., et al. 2019. Loss of Cntnap2 Causes Axonal Excitability Deficits, Developmental Delay in Cortical Myelination, and Abnormal Stereotyped Motor Behavior. Cerebral Cortex, 586-597.
30356053	1:10,000	Baronas, V., et al. 2018. Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations. Nature Communications, 4417.
29963618	not listed	Taylor, A., et al. 2018. Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan. eNeuro, ENEURO.0138-18.2018.
29853631	not listed	Susuki, K., et al. 2018. Glial βII Spectrin Contributes to Paranode Formation and Maintenance. Journal of Neuroscience, 6063-75.
29673258	not listed	Griggs, R., et al. 2018. Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation. ASN Neuro, 1759091418766170.
29491011	1:500	Zhou, L., et al. 2018. Celecoxib ameliorates seizure susceptibility in autosomal dominant lateral temporal epilepsy. The Journal of Neuroscience, 3346-57.
29038243	not listed	Huang, C., et al. 2017. An αII Spectrin-Based Cytoskeleton Protects Large-Diameter Myelinated Axons from Degeneration. Journal of Neuroscience, 11323-11334.
29038240	not listed	Huang, C., et al. 2017. αII Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function. Journal of Neuroscience, 11311-22.
28559325	1:500	Stange-Marten, A., et al. 2017. Input timing for spatial processing is precisely tuned via constant synaptic delays and myelination patterns in the auditory brainstem.. Proceedings of the National Academy of Science of the United States of America, E4851-8.
28370195	not listed	Saifetiarova, J., et al. 2017. Axonal Domain Disorganization in Caspr1 and Caspr2 Mutant Myelinated Axons Affects Neuromuscular Junction Integrity Leading to Muscle Atrophy. Journal of Neuroscience Research, 1373-90.
28322742	1:100	Maglemose, R., et al. 2017. Potassium channel abnormalities are consistent with early axon degeneration of motor axons in the G127X SOD1 mouse model of amyotrophic lateral sclerosis. Experimental Neurology, 154-167.
28270689	1:200	Zhao, J.Y., et al. 2017. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nature communications, 8(1), pp.1-15.. Nature communications, 44576.
28217083	1:200	Taylor, A., et al. 2017. Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function. Frontiers in Cellular Neuroscience, 11.
28148727	not listed	Saifetiarova, J., et al. 2017. Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons. Journal of Neuroscience, 2524-38.
28003466	not listed	D'Este, E., et al. 2017. Ultrastructural anatomy of nodes of Ranvier in the peripheral nervous system as revealed by STED microscopy. PNAS, E191-9.
27463510	not listed	Otani, Y., et al. 2017. Chronic peripheral nerve compression disrupts paranodal axoglial junctions. Muscle & Nerve, 544-54.

Immunohistochemistry: Rat
PMID	Dilution	Publication
30356053	1:10,000	Baronas, V., et al. 2018. Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations. Nature Communications, 4417.
24723263	1:500	Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-99.

Western Blot: Human
PMID	Dilution	Publication
33803465	1:1000	Zhang, Y., et al. 2021. Regulation of K+ Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels. Membranes (Basel), 190.
32311044	1:2000	Lamothe, S., et al. 2020. Slc7a5 alters Kvβ-mediated regulation of Kv1.2. Journal of General Physiology, e201912524.
30593566	1:20,000	Cordeiro, S., et al. 2019. Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric Kv1 channels. PNAS, 1059-64.
29564531	not listed	Willis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. Brain Structure and Function, 2663-71.
28432329	not listed	Desplantes, R., et al. 2017. Affinity biosensors using recombinant native membrane proteins displayed on exosomes: Application to botulinum neurotoxin B receptor. Scientific Reports, 1032.

Western Blot: Mouse
PMID	Dilution	Publication
34910912	not listed	Yokoi, N., et al. 2021. 14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice. Cell Reports, 110107.
33157003	not listed	Kuijpers, M., et al. 2021. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron, 299-313.e9.
31017573	1:500	Carrillo-Reid, L., et al. 2019. Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons. eLife, e40818.
30684388	1:500	Mao, Q., et al. 2019. DNMT3a-triggered downregulation of K2p1.1 gene in primary sensory neurons contributes to paclitaxel-induced neuropathic pain. International Journal of Cancer, 2122-34.
30447021	1:1000	Saifetiarova, J., et al. 2019. Ablation of Cytoskeletal Scaffolding Proteins, Band 4.1B and Whirlin, Leads to Cerebellar Purkinje Axon Pathology and Motor Dysfunction. Journal of Neuroscience Research, 313-31.
30356053	1:10,000	Baronas, V., et al. 2018. Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations. Nature Communications, 4417.
30224722	1:500	Yang, Y.M., et al. 2018. Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain.. Molecular Psychiatry, 2017-35.
29963618	not listed	Taylor, A., et al. 2018. Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan. eNeuro, ENEURO.0138-18.2018.
29564531	not listed	Willis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. . Brain Structure and Function, 2663-2671.
29491011	1:500	Zhou, L., et al. 2018. Celecoxib ameliorates seizure susceptibility in autosomal dominant lateral temporal epilepsy. The Journal of Neuroscience, 3346-57.
29476105	1:1000	Nguyen, L.H., et al. 2018. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Scientific Reports, 3568.
28270689	1:200	Zhao, J.Y., et al. 2017. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nature communications, 8(1), pp.1-15.. Nature communications, 44576.
28148727	not listed	Saifetiarova, J., et al. 2017. Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons. Journal of Neuroscience, 2524-38.
26406915	1:1000	Brügger, V., et al. 2015. HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins.. PLoS Biology, e1002258.
25670860	1:2 (supe)	Nieves-Cintrón, M., et al. 2015. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes.. The Journal of Biological Chemistry, 7918-29.
25485908	1 : 1000	Yokoi, N., et al. 2015. Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.. Nature Medicine, 19-26.
25362471	not listed	Chang, K.J., et al. 2014. Glial ankyrins facilitate paranodal axoglial junction assembly.. Nature Neuroscience, 1673-81.
24494598	not listed	Speca, D.J., et al. 2014. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.. Genes, Brain and Behavior, 394-408.

Western Blot: Rat
PMID	Dilution	Publication
33185190	1:500	Sanders, S.S., et al. 2020. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. eLife, e56058.
32634531	1:20,000	Sánchez-Aguilera, A., et al. 2020. Development of Action Potential Waveform in Hippocampal CA1 Pyramidal Neurons. Neuroscience, 151-67.
31176559	1:5000	Saint-Martin, M., et al. 2019. Impact of anti-CASPR2 autoantibodies from patients with autoimmune encephalitis on CASPR2/TAG-1 interaction and Kv1 expression. Journal of Autoimmunity, 102284.
30515739	1:1000	Wu, Q., et al. 2019. TET1 Overexpression Mitigates Neuropathic Pain Through Rescuing the Expression of μ-Opioid Receptor and Kv1.2 in the Primary Sensory Neurons. Neurotherapeutics, 491-504.
30356053	1:10,000	Baronas, V., et al. 2018. Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations. Nature Communications, 4417.
29056068	1:200	Miao, X., et al. 2017. DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn. Molecular Pain, 1744806917740680.
22675541	not listed	Manning, C.F., et al. 2012. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance.. PLoS One, e38313.

Additional Publications: Unspecified
PMID	Publication
27615452	Schneider, S., et al. 2016. Decrease in newly generated oligodendrocytes leads to motor dysfunctions and changed myelin structures that can be rescued by transplanted cells. Glia, 2201-18.
27168396	Berret, E., et al. 2016. Functional and structural properties of ion channels at the nerve terminal depends on compact myelin. Journal of Physiology, 5593-5609.
26949968	Chihabi, K., et al. 2016. Intra-cerebellar infusion of the protein kinase Mzeta (PKMζ) inhibitor ZIP disrupts eyeblink classical conditioning. Behavioral Neuroscience, 563-71.
26840208	Hivert, B., et al. 2016. Assembly of juxtaparanodes in myelinating DRG culture: Differential clustering of the Kv1/Caspr2 complex and scaffolding protein 4.1B.. Glia, 840-52.
26763782	Rash, J., et al. 2016. KV1 channels identified in rodent myelinated axons, linked to Cx29 in innermost myelin: support for electrically active myelin in mammalian saltatory conduction. Journal of Neurophysiology, 1836-59.
26646078	Baronas, V.A., et al. 2016. Determinants of frequency-dependent regulation of Kv1.2-containing potassium channels.. Channels (Austin)., 158-66.
26240432	Peltola, M.A., et al. 2016. AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes.. Schizophrenia Bulletin, 191-201.
26342649	Wang, P., et al. 2015. Short-Term Sleep Disturbance-Induced Stress Does not Affect Basal Pain Perception, but Does Delay Postsurgical Pain Recovery. Journal of Pain, 1186-99.
26305015	Ford, M.C., et al. 2015. Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing.. Nature Communications, 8073.
26269648	Kole, M.J., et al. 2015. Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing.. Journal of Neuroscience, 11433-44.
26269632	Smith, K., et al. 2015. Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice. Journal of Neuroscience, 11221-32.
26226133	van Vliet, A.C., et al. 2015. Human Neuroma-in-Continuity Contains Focal Deficits in Myelination. Journal of Neuropathology & Experimental Neurology, 901-11.
25846372	Yoo, S.W., et al. 2015. Sialylation regulates brain structure and function.. The FASEB Journal, 3040-53.
25751627	Syrbe, S., et al. 2015. De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy.. Nature Genetics, 393-9.
25716850	Baronas, V.A., et al. 2015. Use-dependent activation of neuronal Kv1.2 channel complexes.. Journal of Neuroscience, 3515-24.
25413837	Miyazaki, H., et al. 2014. Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum.. Nature Communications, 5525.
25119334	Salewski, R.P., et al. 2014. Transplantation of neural stem cells clonally derived from embryonic stem cells promotes recovery after murine spinal cord injury.. Stem Cells and Development, 36-50.
24849898	Zenker, J., et al. 2014. A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells.. Glia, 1502-12.
24723263	Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-99.
24719114	Lehnert, S., et al. 2014. Action potential generation in an anatomically constrained model of medial superior olive axons.. Journal of Neuroscience, 5370-84.
24631676	Kim, K.Y., et al. 2014. Localization and expression of CaBP1/caldendrin in the mouse brain.. Neuroscience, 33-47.
24498366	Bagchi, B., et al. 2014. Disruption of myelin leads to ectopic expression of K(V)1.1 channels with abnormal conductivity of optic nerve axons in a cuprizone-induced model of demyelination.. PLoS One, e87736.
24494598	Speca, D.J., et al. 2014. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.. Genes, Brain and Behavior, 394-408.
24477962	King, A.N., et al. 2014. A unique ion channel clustering domain on the axon initial segment of mammalian neurons.. Journal of Comparative Neurology, 2594-608.
24472174	Fan, .L, et al. 2014. Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons.. Molecular Pain, 8.
24200924	Liu, Q., et al. 2014. Heterogeneous intrinsic excitability of murine spiral ganglion neurons is determined by Kv1 and HCN channels.. Neuroscience, 96-110.
23945775	Kyle BD, et al. 2013. The large conductance, calcium-activated K+ (BK) channel is regulated by cysteine string protein.. Scientific Reports, 2447.
23864679	Ruff, C.A., et al. 2013. Effects of adult neural precursor-derived myelination on axonal function in the perinatal congenitally dysmyelinated brain: optimizing time of intervention, developing accurate prediction models, and enhancing performance.. Journal of Neuroscience, 11899-915.
23864368	Wang, W., et al. 2013. Association of the Kv1 family of K+ channels and their functional blueprint in the properties of auditory neurons as revealed by genetic and functional analyses. Journal of Neurophysiology, 1751-64.
23792947	Zhao, X., et al. 2013. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons.. Nature Neuroscience, 1024-31.
23554500	Buffington, S.A., et al. 2013. Na+ channel-dependent recruitment of Navβ4 to axon initial segments and nodes of Ranvier.. Journal of Neuroscience, 6191-202.
23536771	Brewster, A.L., et al. 2013. Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.. PLoS One, e57808.
23439123	Campanac, E., et al. 2013. Enhanced intrinsic excitability in basket cells maintains excitatory-inhibitory balance in hippocampal circuits.. Neuron, 712-22.
23359569	Lee, S.M., et al. 2013. Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot-Marie-Tooth disease type 1C.. Human Molecular Genetics, 1755-70.
23318870	Ovsepian, S.V., et al. 2013. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.. The Journal of Physiology, 1771-91.
23300814	Takano, M., et al. 2012. MRI characterization of paranodal junction failure and related spinal cord changes in mice.. PLoS One, e52904.
23119056	Sánchez-Ponce, D., et al. 2012. Developmental expression of Kv potassium channels at the axon initial segment of cultured hippocampal neurons.. PLoS One, e48557.
23052293	Uchida, N., et al. 2012. Human neural stem cells induce functional myelination in mice with severe dysmyelination.. Science Translational Medicine, 155ra136.
22826130	Sanchez, J.T., et al. 2012. Control of neuronal excitability by NMDA-type glutamate receptors in early developing binaural auditory neurons.. The Journal of Physiology, 4801-18.
22806400	Seidl, A.H., et al. 2012. Transgenic quail as a model for research in the avian nervous system: a comparative study of the auditory brainstem.. Journal of Comparative Neurology, 5-23.
22764231	Williams, M.R., et al. 2012. Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellum.. Journal of Neuroscience, 9228-9237.
22699912	Oluich, L.J., et al. 2012. Targeted ablation of oligodendrocytes induces axonal pathology independent of overt demyelination.. Journal of Neuroscience, 8317-30.
22649228	Zenker, J., et al. 2012. Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus.. Journal of Neuroscience, 7493-8.
22641786	Glasscock, E., et al. 2012. Transcompartmental reversal of single fibre hyperexcitability in juxtaparanodal Kv1.1-deficient vagus nerve axons by activation of nodal KCNQ channels.. The Journal of Physiology, 3913-26.
22560931	Jukkola, P.I., et al. 2012. K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.. Neurobiology of Disease, 280-93.
22496557	Powers, B.E., et al. 2012. Axonal thinning and extensive remyelination without chronic demyelination in spinal injured rats.. Journal of Neuroscience, 5120-5.
22492029	Buttermore, E.D., et al. 2012. Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development.. Journal of Neuroscience, 4724-42.
22473710	Irani, S.R., et al. 2012. Morvan syndrome: clinical and serological observations in 29 cases.. Annals of Neurology, 241-55.
22323722	Deverman, B.E., et al. 2012. Exogenous leukemia inhibitory factor stimulates oligodendrocyte progenitor cell proliferation and enhances hippocampal remyelination.. Journal of Neuroscience, 2100-9.
22291039	Ivanovic, A., et al. 2012. The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves.. The Journal of Biology, 337-44.
22285261	Shimoda, Y., et al. 2012. A cis-complex of NB-2/contactin-5 with amyloid precursor-like protein 1 is localized on the presynaptic membrane.. Neuroscience Letters, 148-53.
22218089	He, S., et al. 2012. Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.. Neuropsychopharmacology, 1338-56.
21676499	Wykes, R., et al. 2012. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice.. Neurobiology of Aging, 1609-23.
22131424	Kaphzan, H., et al. 2011. Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome.. Journal of Neuroscience, 17637-48.
22056818	Peltola, M.A., et al. 2011. AMIGO is an auxiliary subunit of the Kv2.1 potassium channel.. EMBO Reports, 1293-99.
21958379	Duflocq, A., et al. 2011. Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B.. BMC Biology, 66.
21911612	Joseph, B.K., et al. 2011. Postsynaptic density-95 scaffolding of Shaker-type K⁺ channels in smooth muscle cells regulates the diameter of cerebral arteries.. The Journal of Physiology, 5143-52.
21900579	Shakkottai, V.G., et al. 2011. Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3.. Journal of Neuroscience, 13002-14.
21674494	Brandao, K.E., et al. 2011. A-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons.. Journal of Comparative Neurology, 81-99.
21632949	Hirtz, J.J., et al. 2011. Cav1.3 calcium channels are required for normal development of the auditory brainstem.. Journal of Neuroscience, 8280-94.
21632923	Buttermore, E.D., et al. 2011. The cytoskeletal adaptor protein band 4.1B is required for the maintenance of paranodal axoglial septate junctions in myelinated axons.. Journal of Neuroscience, 8013-24.
21618613	Shroff, S., et al. 2011. Paranodal permeability in "myelin mutants".. Glia, 1447-57.
21602278	Gu, C., et al. 2011. Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons.. The Journal of Biological Chemistry, 25835-47.
21490210	Gross, C., et al. 2011. Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2.. Journal of Neuroscience, 5693-98.
21357749	Vacher, H., et al. 2011. Cdk-mediated phosphorylation of the Kvβ2 auxiliary subunit regulates Kv1 channel axonal targeting.. The Journal of Biology, 813-24.
21352098	Al-Sabi, A., et al. 2011. Position-dependent attenuation by Kv1.6 of N-type inactivation of Kv1.4-containing channels.. Biochemical Journal, 389-96.
21248132	Pohl, H.B., et al. 2011. Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage.. Journal of Neuroscience, 1069-80.
21233214	Fulton, S., et al. 2011. Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.. The Journal of Biological Chemistry, 9360-72.
21224222	Karcz, A., et al. 2011. Low-voltage activated Kv1.1 subunits are crucial for the processing of sound source location in the lateral superior olive in mice.. The Journal of Physiology, 1143-57.
21110920	Song, M.Y., et al. 2010. Contribution of the delayed-rectifier potassium channel Kv2.1 to acute spinal cord injury in rats.. BMB Reports, 756-60.
20980605	Changm, K.J., et al. 2010. Oligodendrocyte myelin glycoprotein does not influence node of ranvier structure or assembly.. Journal of Neuroscience, 14476-81.
20962009	Devaux, J.J., et al. 2010. The C-terminal domain of ßIV-spectrin is crucial for KCNQ2 aggregation and excitability at nodes of Ranvier.. The Journal of Physiology, 4719-30.
20888080	Shepherd, M.N., et al. 2010. Paranodal reorganization results in the depletion of transverse bands in the aged central nervous system. Neurobiology of Aging, 203.e13-203.e24.
20876197	Zhong, X.Z., et al. 2010. Stromatoxin-sensitive, heteromultimeric Kv2.1/Kv9.3 channels contribute to myogenic control of cerebral arterial diameter. The Journal of Physiology, 4519-37.
20858739	Crawford, D.K., et al. 2010. Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination.. Brain, 2999-3016.
20838243	Howell, O.W., et al. 2010. Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis.. Journal of Neuropathology & Experimental Neurology, 1017-33.
20802489	Padmanabhan, K., et al. 2010. Intrinsic biophysical diversity decorrelates neuronal firing while increasing information content.. Nature Neuroscience, 1276-82.
20669363	Hovis, K.R., et al. 2010. A simple method of in vitro electroporation allows visualization, recording, and calcium imaging of local neuronal circuits.. Journal of Neuroscience Methods, 1-10.
20575068	Gazula, V.R., et al. 2010. Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons.. Journal of Comparative Neurology, 3205-20.
20506478	Mierzwa, A.J., et al. 2010. Role of transverse bands in maintaining paranodal structure and axolemmal domain organization in myelinated nerve fibers: effect on longevity in dysmyelinated mutant mice. Journal of Comparative Neurology, 2841-53.
20164332	Horresh, I., et al. 2010. Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B.. Journal of Neuroscience, 2480-9.
20133599	Fukata, Y., et al. 2010. Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy.. Proceedings of the National Academy of Science of the United States of America, 3799-804.
20089912	Ogawa, Y., et al. 2010. ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.. Journal of Neuroscience, 1038-48.
19379822	Dupree, J.L., et al. 2010. Myelin, DIGs, and membrane rafts in the central nervous system.. Prostaglandins & Other Lipid Mediators, 118-29.

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Anti-Kv1.2 K+ Channel Antibody (K14/16)

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Anti-Kv1.2 K+ Channel Antibody (K14/16)

Anti-Kv1.2 K+ Channel Antibody SKU: 75-008

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Anti-Kv1.2 K+ Channel Antibody
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