Anti-GluN1/NR1 Glutamate Receptor Antibody FL490 Conjugate (N308/48)

Name: Anti-GluN1/NR1 Glutamate Receptor Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-272-FL490
Price: 543.0 USD
Availability: InStock

Our mouse GluN1/NR1 glutamate receptor FL490 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N308/48. It detects human, mouse, and rat GluN1/NR1 glutamate receptor and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-GluN1/NR1 Glutamate Receptor Antibody FL490 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-272-FL490

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GluN1/NR1 glutamate receptor

Scientific Background

Glutamate receptor 1, NMDA 1, or GluN1/NR1 also known as subunit 1 of the N-methyl-D-aspartate (NMDA) receptor. It is a member of the glutamate receptor channel superfamily and is a heteromeric glutamate-gated calcium ion channel. GluN1 is essential for synaptic function in the brain. GluN1 is expressed throughout the brain in cerebellum, thalamus, olfactory bulb and cortex in the membrane at postsynaptic density. GluN1 plays a key role in synaptogenesis, synaptic plasticity, memory acquisition and learning. Mutations in the GluN1 gene are associated with intellectual disability and cortical visual impairment and movement disorders.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N308/48

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Grin1 Nmdar1

Molecular Weight

105 kDa

Immunogen

Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1 (accession number P35439) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939976

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)

UniProt ID

P35439-2

Shipping

Shipped on ice packs

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Anti-GluN1/NR1 Glutamate Receptor Antibody FL490 Conjugate (N308/48)

SKU: 75-272-FL490

Product Details

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