Human Mouse Rat
Fusion protein amino acids 1-192 (exon 1a, exon 4 and constant region) of rat TRIP8b (also known as TPR-containing Rab8b-interacting protein, Peroxisome biogenesis factor 5-like, Peroxin-5 or PEX5-related/like protein, Pex5Rp, Pex5l, Pex5r, Pex2, Pxr2, accession number Q925N3)
Mouse: 97% identity (147/151 amino acids identical)
Human: 83% identity (180/216 amino acids identical)
Specific for exon 1b (does not react with TRIP8b isoforms containing exons 1a, 2 or 4)
PEX5-related protein (PEX2-related protein) (PEX5-like protein) (Peroxin-5-related protein) (Tetratricopeptide repeat-containing Rab8b-interacting protein) (Pex5Rp) (TRIP8b)
Pex5l Pex2 Pex5r Pxr2
TC Supernatant: AB_10675330
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
- Zhou M1, Luo P1, Lu Y1, Li CJ1, Wang DS1, Lu Q2, Xu XL2, He Z3, Guo LJ4.. (2015), 'Imbalance of HCN1 and HCN2 expression in hippocampal CA1 area impairs spatial learning and memory in rats with chronic morphine exposure..' Prog Neuropsychopharmacol Biol Psychiatry.. 10.1016/j.pnpbp.2014.09.010.
- Li CJ1, Lu Y, Zhou M, Zong XG, Li C, Xu XL, Guo LJ, Lu Q.. (2014), 'Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area in rats with chronic cerebral hypoperfusion..' Mol Neurobiol.. 10.1007/s12035-014-8736-3.
- Piskorowski R1, Santoro B, Siegelbaum SA.. (2011), 'TRIP8b splice forms act in concert to regulate the localization and expression of HCN1 channels in CA1 pyramidal neurons..' Neuron.. 10.1016/j.neuron.2011.03.023.