Neuronal Cell Adhesion Molecule is encoded by the gene NRCAM. NRCAM is a member of the immunoglobulin superfamily, L1/neurofascin/NgCAM family. NRCAM is an ankyrin-binding protein that is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. NRCAM also may play a role in cell-cell communication via signalling from its intracellular domain to the actin cytoskeleton during directional cell migration. NRCAM is expressed in the brain. Diseases associated with NRCAM include Masa Syndrome and Autism.
Fusion protein amino acids 30-845 (extracellular domain) of mouse NrCAM (also known as Neuronal cell adhesion molecule, Ankyrin-binding cell adhesion molecule, Neuronal surface protein Bravo, NgCAM-related cell adhesion molecule and KIAA0343, accession number Q810U4)
Rat: 96% identity (795/822 amino acids identical)
Human: 91% identity (753/822 amino acids identical)
~50% identity with Neurofascin
Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (mBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)
TC Supernatant: AB_2315899
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.