Neuronal Cell Adhesion Molecule is encoded by the gene NRCAM. NRCAM is a member of the immunoglobulin superfamily, L1/neurofascin/NgCAM family. NRCAM is an ankyrin-binding protein that is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. NRCAM also may play a role in cell-cell communication via signalling from its intracellular domain to the actin cytoskeleton during directional cell migration. NRCAM is expressed in the brain. Diseases associated with NRCAM include Masa Syndrome and Autism.
Purified by Protein A chromatography
Fusion protein amino acids 30-845 (extracellular domain) of mouse NrCAM (accession number Q810U4) produced recombinantly in E. Coli
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL650 Ex: 655 nm, Em: 676 nm
No cross-reactivity reported
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.