Anti-NrCAM Antibody FL650 Conjugate (N343/26)

Name: Anti-NrCAM Antibody FL650 Conjugate
Brand: NeuroMab
SKU: 75-325-FL650
Price: 486.0 USD
Availability: InStock

Our mouse NrCAM FL650 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N343/26. It detects mouse and rat NrCAM and is purified by Protein A chromatography. Works in ICC.

Anti-NrCAM Antibody FL650 Conjugate

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Species Reactivity

Mouse, Rat

Applications

ICC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

Biotin

Carrier-Free

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Data Sheet

SKU: 75-325-FL650

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

NrCAM

Scientific Background

Neuronal Cell Adhesion Molecule is encoded by the gene NRCAM. NRCAM is a member of the immunoglobulin superfamily, L1/neurofascin/NgCAM family. NRCAM is an ankyrin-binding protein that is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. NRCAM also may play a role in cell-cell communication via signalling from its intracellular domain to the actin cytoskeleton during directional cell migration. NRCAM is expressed in the brain. Diseases associated with NRCAM include Masa Syndrome and Autism.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N343/26

Isotype

IgG2a

Applications

ICC

Host Species

Mouse

Gene Name

Nrcam Kiaa0343

Molecular Weight

160 kDa

Immunogen

Fusion protein amino acids 30-845 (extracellular domain) of mouse NrCAM (accession number Q810U4) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2940127

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Bravo; Neuronal cell adhesion molecule; C130076O07Rik; Nr-CAM; mKIAA0343; Neuronal surface protein Bravo; mBravo; NgCAM-related cell adhesion molecule; neuron-glia-CAM-related cell adhesion molecule; Ng-CAM-related

UniProt ID

Q810U4
UniProt Summary: Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

NCBI Gene ID

319504

Shipping

Shipped on ice packs

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Anti-NrCAM Antibody FL650 Conjugate (N343/26)

SKU: 75-325-FL650

Product Details

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