Sodium channel subunit beta-3 or Navbeta3 Na+ channel is encoded by SCN3B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. Navß3 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel. Nabß3 is expressed in many tissues, including the central and peripheral nervous system, heart and pancreatic endocrine cells. Diseases associated with SCN3A include forms of Epilepsy and Encephalopathy.
Fusion protein amino acids 1-215 (full-length) of rat Navbeta3 (also known as Sodium channel subunit beta-3, Scn3b and KIAA1158, accession number Q9JK00)
Mouse: 99% identity (214/215 amino acids identical)
Human: 98% identity (211/215 amino acids identical)
50% identity with Navbeta1, Navbeta2 or Navbeta4
Does not cross-react with Navbeta1, Navbeta2 or Navbeta4
Sodium channel subunit beta-3
TC Supernatant: AB_2336910
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.