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Products: Primary Antibodies

Anti-Nav1.2 Na+ channel Antibody (K69/3)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-024
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-024
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG2a

Species Reactivity:

Human Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

IHC IP WB

Target Description:

Nav1.2 Na+ channel (sodium channel, voltage-gated, type II, alpha subunit/ SCN2A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn2a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.1 Na+ channel is a sodium selective channel that maintains Na+ homeostasis by allowing Na+ ions to pass in accordance of their electrochemical gradient.Nav1.2 Na+ channel is implicated in the regulation of hippocampal replay, whose waves ripples (SPW-R) condition memories. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several cases of seizures, autism and bipolar disorders.

Immunogen:

Fusion protein amino acids 1882-2005 (cytoplasmic C-terminus) of rat rat Nav1.2 (accession number P04775); Human: 94% identity (117/124); Mouse: 100% identity (124/124)

Cross Reactivity:

Lack of cross-reactivity against Nav1.1, Nav1.3, Nav1.6 verified

Protein Name(s):

Nav1.2 Na+ channel

Gene Name(s):

Scn2a Scn2a1

Antibody Registry ID:

Purified: AB_2184030
TC Supernatant: AB_10673401


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Immunohistochemistry:
This antibody shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Molecular Weight:

˜250 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.