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Products: Primary Antibodies

Anti-Mitofusin-1 Antibody (N111/24)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-162
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-162
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC WB

Target Description:

Mitofusin 1, or transmembrane GTPase Mfn1 (MFN1) is a mitochondrial membrane protein with GTPase activity that functions to aid mitochondrial clustering and fusion. It may also play a role in mitochondrial metabolism. It is expressed in the outer membrane of mitochondria in many tissues, including heart and testis. Diseases associated with MFN1 include Optic Atrophy 1 and Autosomal Recessive Spastic Paraplegia .

Immunogen:

Fusion protein amino acids 350-580 of mouse Mitofusin-1 (also known as transmembrane GTPase Mfn1, accession number Q811U4); Rat: 99% identity (229/231 amino acids identical); Human: 89% identity (207/231 amino acids identical); ~55 % identity with Mitofusin-2

Cross Reactivity:

No cross-reactivity against Mitofusin-2

Protein Name(s):

Mitofusin-1

Gene Name(s):

Mfn1

Antibody Registry ID:

Purified: AB_2266317
TC Supernatant: AB_10675293


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Knockout Validation:

This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).

Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Molecular Weight:

80 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.