Leucine Rich Repeat Kinase 1 is encoded by the gene LRRK1. LRRK1 is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, ROCO subfamily. LRRK1 is a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. LRRK1 is thought to play a role in the regulation of bone mass. LRRK1 is overexpressed in lymph node and uterus. Diseases associated with LRRK1 include Osteosclerotic Metaphyseal Dysplasia and Parkinson Disease 3, Autosomal Dominant.
Fusion protein amino acids 1695-2015 (C-terminus) of human LRRK1 (also known as Leucine-rich repeat serine/threonine-protein kinase 1 and KIAA1790, accession number Q38SD2). Mouse: 81% identity (263/321 amino acids identical) Rat: 79% identity (254/321 amino acids identical) <50% identity with LRRK2 This NeuroMab antibody is considered "Restricted" and is therefore not available for commercial re-distribution on a for-profit basis.
Does not cross-react with LRRK2
Leucine-rich repeat serine/threonine-protein kinase 1 (EC 18.104.22.168)
TC Supernatant: AB_2315879
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.