Human Mouse Rat
ICC IHC WB
ERG3 (ether-a-go-go–related gene 3), Potassium voltage-gated channel subfamily H member 7, or Kv11.3 potassium channel is encoded by the gene Kcnh7 and is a member of the ERG family of voltage activated potassium channels. Kv11.3 is a pore forming, alpha subunit of the potassium channel. Erg channels play roles in regulating the resting membrane potential and action potential duration. Kv11.3 is detected in total brain, in superior cervical, mesenteric and celiac ganglia, and at very low levels in retina and is also found in pituitary.
Fusion protein amino acids 894-1059 (cytoplasmic C-terminus) of rat Kv11.3 (also known as Voltage-gated potassium channel subunit Kv11.3, Ether-a-go-go-related gene potassium channel 3, Ether-a-go-go-related protein 3, Eag-related protein 3, Potassium voltage-gated channel subfamily H member 7, Erg3 and Kcnh7, accession number O54852)
Mouse: 93% identity (155/166 amino acids identical)
Human: 79% identity (131/166 amino acids identical)
50% identity with Kv11.1 and Kv11.2
Potassium voltage-gated channel subfamily H member 7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (Voltage-gated potassium channel subunit Kv11.3)
TC Supernatant: AB_2560963
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.